Janus kinases (Jaks), signal transducers and activators of transcription (Stats) form a unique, fast track for signal transduction from cell surface receptors to target genes. Jak-Stat signalling contributes in many ways to the integrity of organisms and disturbance of this signalling avenue causes disease in mammalian organisms, including humans.

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The present initiative SFB-JakStat is a special research programme granted by the Austrian Science Fund FWF.

It pools existing resources by creating a veritable JakStat-platform that is amongst the largest in Europe, Asia, Australia or North America. This state-of-the-art scientific network consists of six basic research-oriented groups from three different universities and two translational research performing institutes, namely the University of Veterinary Medicine Vienna including its core facility Biomodels Austria, the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna, the Ludwig Boltzmann Institute for Cancer Research and the Research Center for Molecular Medicine of the Austrian Academy of Sciences.



SFB-JakStat presents combined efforts to address the role of Jaks and/or Stats in two important categories of disease:

infection/inflammation and cancer. An intimate inter-relationship between both processes is emerging from recent literature. Hence, particular efforts will be made - and present a main raison d'etre for the consortium - to understand Jaks and Stats signals and mechanisms linking infection, inflammation and cancer.