Work Packages

Managment & Coordination

Text

Inflammation & Immune Response

• Canonical and noncanonical Stat signaling
• Stat1 target genes in stress and inflammation
• Tissue-specific Tyk2 functions
• Stat1 in leukaemia progression
• Stat3/Stat5 in inflammation-induced liver damage

Hematopoiesis & Leukaemogenesis

• Stat5/3/1 junction in erythropoiesis and leukaemia
• Stat5 structure-function interrelation in leukaemia
• Co-operation of Jak2 signals in erythropoiesis and leukaemogenesis
• Jak2/Stat5 signaling in B lymphomagenesis

Carcinoma

• Stats in epithelial-mesenchymal transition (EMT) and metasasis
• Stats in chemical or inflammation-induced liver cancer
• Stats in hepatic EMT and fibrosis
• Jak-Stat interaction partners in livercancer

Novel Mechanisms of Action

• Target genes for Stat phosphospecies and Stat tetramers
• Synergy of p38MAPK and Stat1 in transcription
• Jak interaction partners and kinase dependence of Jak function
• Co-operation of TGF- signaling and Stat3