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Fragiadaki, M., Lannoy, M., Themanns, M., Maurer, B., Leonhard, W.N., Peters, D.J., Moriggl, R., and Ong, A.C. (2017).
STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease. Kidney Int 2017 Jan 16. [Epub ahead of print] doi: 10.1016/j.kint.2016.10.039.

Freund, P., Kerenyi, M.A., Hager, M., Wagner, T., Wingelhofer, B., Pham, H.T., Elabd, M., Han, X., Valent, P., Gouilleux, F., Sexl, V., Kramer, O.H., Groner, B., and Moriggl, R. (2017).
O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies. Leukemia 2017 Jan 11. [Epub ahead of print] doi: 10.1038/leu.2017.4.

Ghanem, S., Friedbichler, K., Boudot, C., Bourgeais, J., Gouilleux-Gruart, V., Regnier, A., Herault, O., Moriggl, R., and Gouilleux, F. (2017).
STAT5A/5B-specific expansion and transformation of hematopoietic stem cells. Blood Cancer J 7, e514. doi: 10.1038/bcj.2016.124.

Kaltenecker, D., Mueller, K.M., Benedikt, P., Feiler, U., Themanns, M., Schlederer, M., Kenner, L., Schweiger, M., Haemmerle, G., and Moriggl, R. (2017).
Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice. Diabetologia 60, 296-305. doi: 10.1007/s00125-016-4152-8

Linke, M., Pham, H.T., Katholnig, K., Schnoller, T., Miller, A., Demel, F., Schutz, B., Rosner, M., Kovacic, B., Sukhbaatar, N., Niederreiter, B., Bluml, S., Kuess, P., Sexl, V., Muller, M., Mikula, M., Weckwerth, W., Haschemi, A., Susani, M., Hengstschlager, M., Gambello, M.J., and Weichhart, T. (2017).
Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol 2017 Jan 16. [Epub ahead of print] 10.1038/ni.3655.

Mueller, K.M., Hartmann, K., Kaltenecker, D., Vettorazzi, S., Bauer, M., Mauser, L., Amann, S., Jall, S., Fischer, K., Esterbauer, H., Muller, T.D., Tschop, M.H., Magnes, C., Haybaeck, J., Scherer, T., Bordag, N., Tuckermann, J.P., and Moriggl, R. (2017).
Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and Hfd-Induced Obesity, and Impairs the Feeding-Fasting Transition. Diabetes 66, 272-286. doi: 10.2337/db16-0381.



Balligand, T., Achouri, Y., Pecquet, C., Chachoua, I., Nivarthi, H., Marty, C., Vainchenker, W., Plo, I., Kralovics, R., and Constantinescu, S.N. (2016).
Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin. Leukemia 2016 Feb 29 [Epub ahead of print] doi: 10.1038/leu.2016.47.

Bottos, A., Gotthardt, D., Gill, J.W., Gattelli, A., Frei, A., Tzankov, A., Sexl, V., Wodnar-Filipowicz, A., and Hynes, N.E. (2016).
Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nat Commun 7, 12258. doi: 10.1038/ncomms12258

Bourgeais, J., Ishac, N., Medrzycki, M., Brachet-Botineau, M., Desbourdes, L., Gouilleux-Gruart, V., Pecnard, E., Rouleux-Bonnin, F., Gyan, E., Domenech, J., Mazurier, F., Moriggl, R., Bunting, K.D., Herault, O., and Gouilleux, F. (2016).
Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses. Oncotarget 2016 Aug 22. [Epub ahead of print] doi: 10.18632/oncotarget.11480.

Castiglia, V., Piersigilli, A., Ebner, F., Janos, M., Goldmann, O., Dambock, U., Kroger, A., Weiss, S., Knapp, S., Jamieson, A.M., Kirschning, C., Kalinke, U., Strobl, B., Muller, M., Stoiber, D., Lienenklaus, S., and Kovarik, P. (2016).
Type I Interferon Signaling Prevents IL-1beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19, 375-387. doi: 10.1016/j.chom.2016.02.003.

Chachoua, I., Pecquet, C., El-Khoury, M., Nivarthi, H., Albu, R.I., Marty, C., Gryshkova, V., Defour, J.P., Vertenoeil, G., Ngo, A., Koay, A., Raslova, H., Courtoy, P.J., Choong, M.L., Plo, I., Vainchenker, W., Kralovics, R., and Constantinescu, S.N. (2016).
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood 127, 1325-1335. doi: 10.1182/blood-2015-11-681932

Decker, T. (2016).
Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation. EMBO J 2016 Feb 18. pii: e201693974. [Epub ahead of print] Doi: 10.15252/embj.201693974

Floss, D.M., Klocker, T., Schroder, J., Lamertz, L., Mrotzek, S., Strobl, B., Hermanns, H., and Scheller, J. (2016).
Defining the functional binding sites of Interleukin 12 receptor beta1 and Interleukin 23 receptor to Janus kinases. Mol Biol Cell 2016 May 18. [Epub ahead of print] doi: 10.1091/mbc.E14-12-1645.

Gotthardt, D., Putz, E.M., Grundschober, E., Prchal-Murphy, M., Straka, E., Kudweis, P., Heller, G., Bago-Horvath, Z., Witalisz-Siepracka, A., Cumaraswamy, A.A., Gunning, P.T., Strobl, B., Muller, M., Moriggl, R., Stockmann, C., and Sexl, V. (2016).
STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion. Cancer Discov 6, 414-429. Doi: 10.1158/2159-8290.CD-15-0732

Harutyunyan, A.S., Giambruno, R., Krendl, C., Stukalov, A., Klampfl, T., Berg, T., Chen, D., Milosevic Feenstra, J.D., Jager, R., Gisslinger, B., Gisslinger, H., Rumi, E., Passamonti, F., Pietra, D., Muller, A.C., Parapatics, K., Breitwieser, F.P., Herrmann, R., Colinge, J., Bennett, K.L., Superti-Furga, G., Cazzola, M., Hammond, E., and Kralovics, R. (2016).
Germline RBBP6 mutations in familial myeloproliferative neoplasms. Blood 127, 362-365. DOI 10.1182/blood-2015-09-668673

Javaheri, T., Kazemi, Z., Pencik, J., Pham, H.T., Kauer, M., Noorizadeh, R., Sax, B., Nivarthi, H., Schlederer, M., Maurer, B., Hofbauer, M., Aryee, D.N., Wiedner, M., Tomazou, E.M., Logan, M., Hartmann, C., Tuckermann, J.P., Kenner, L., Mikula, M., Dolznig, H., Uren, A., Richter, G.H., Grebien, F., Kovar, H., and Moriggl, R. (2016).
Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell Death Dis 7, e2419. doi: 10.1038/cddis.2016.268

Klose, R., Krzywinska, E., Castells, M., Gotthardt, D., Putz, E.M., Kantari-Mimoun, C., Chikdene, N., Meinecke, A.K., Schrodter, K., Helfrich, I., Fandrey, J., Sexl, V., and Stockmann, C. (2016).
Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun 7, 12528. doi: 10.1038/ncomms12528

Maier, B.B., Hladik, A., Lakovits, K., Korosec, A., Martins, R., Kral, J.B., Mesteri, I., Strobl, B., Muller, M., Kalinke, U., Merad, M., and Knapp, S. (2016).
Type I interferon promotes alveolar epithelial type II cell survival during pulmonary S. pneumoniae infection and sterile lung injury in mice. Eur J Immunol 2016 June 17. [Epub ahead of print] doi: 10.1002/eji.201546201.

Majoros, A., Platanitis, E., Szappanos, D., Cheoan, H.J., Vogl, C., Shukla, P., Stark, G.R., Sexl, V., Schreiber, R.D., Schindler, C., Müller, M., and Decker, T. (2016).
Response to interferons and antibacterial innate immunity in absence of tyrosine-phosphorylated STAT1. EMBO Rep. 17, 367-382. doi: 10.15252/embr.201540726

Marty, C., Pecquet, C., Nivarthi, H., El-Khoury, M., Chachoua, I., Tulliez, M., Villeval, J.L., Raslova, H., Kralovics, R., Constantinescu, S.N., Plo, I., and Vainchenker, W. (2016).
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood 127, 1317-1324. doi: 10.1182/blood-2015-11-679571

Milosevic Feenstra, J.D., Nivarthi, H., Gisslinger, H., Leroy, E., Rumi, E., Chachoua, I., Bagienski, K., Kubesova, B., Pietra, D., Gisslinger, B., Milanesi, C., Jager, R., Chen, D., Berg, T., Schalling, M., Schuster, M., Bock, C., Constantinescu, S.N., Cazzola, M., and Kralovics, R. (2016).
Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms. Blood 127, 325-332. DOI 10.1182/blood-2015-07-661835

Mueller, K.M., Hartmann, K., Kaltenecker, D., Vettorazzi, S., Bauer, M., Mauser, L., Amann, S., Jall, S., Fischer, K., Esterbauer, H., Muller, T.D., Tschop, M.H., Magnes, C., Haybaeck, J., Scherer, T., Bordag, N., Tuckermann, J.P., and Moriggl, R. (2016).
Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and Hfd-Induced Obesity, and Impairs the Feeding-Fasting Transition. Diabetes Sept 20 [Epub ahead of print] doi: 10.2337/db16-0381.

Nivarthi, H., Chen, D., Cleary, C., Kubesova, B., Jaeger, R., Bogner, E., Marty, C., Pecquet, C., Vainchenker, W., Constantinescu, S.N., and Kralovics, R. (2016).
Thrombopoietin receptor is required for the oncogenic function of CALR mutants. Leukemia 2016 Feb 17. [Epub ahead of print] doi: 10.1038/leu.2016.32

Nivarthi, H., Gordziel, C., Themanns, M., Kramer, N., Eberl, M., Rabe, B., Schlederer, M., Rose-John, S., Knosel, T., Kenner, L., Freund, P., Aberger, F., Han, X., Kralovics, R., Dolznig, H., Jennek, S., Friedrich, K., and Moriggl, R. (2016).
The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. Oncotarget 2016 May 12. [Epub ahead of print] doi: 10.18632/oncotarget.9315.

Park, J., Kim, S., Joh, J., Remick, S.C., Miller, D.M., Yan, J., Kanaan, Z., Chao, J.H., Krem, M.M., Basu, S.K., Hagiwara, S., Kenner, L., Moriggl, R., Bunting, K.D., and Tse, W. (2016).
MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling. Oncotarget 2016 Jun 1. [Epub ahead of print] doi: 10.18632/oncotarget.9759.

Pencik, J., Pham, H.T., Schmoellerl, J., Javaheri, T., Schlederer, M., Culig, Z., Merkel, O., Moriggl, R., Grebien, F., and Kenner, L. (2016).
JAK-STAT signaling in cancer: From cytokines to non-coding genome. Cytokine 2016 Jun 24 [Epub ahead of print] doi: 10.1016/j.cyto.2016.06.017.

Putz, E.M., Majoros, A., Gotthart, D., Prchal-Murphy, M., Zebedin-Brandl, E., Fux, D.A., Schlattl, A., Schreiber, R.D., Carotta, S., Müller, M., Gerner, C., Decker, T., and Sexl, V. (2016).
Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity. OncoImmunology 2016 May 19. [Epub ahead of print] doi: 10.1080/2162402X.2016.1186314.

Themanns, M., Mueller, K.M., Kessler, S.M., Golob-Schwarzl, N., Mohr, T., Kaltenecker, D., Bourgeais, J., Paier-Pourani, J., Friedbichler, K., Schneller, D., Schlederer, M., Zebedin-Brandl, E., Terracciano, L.M., Han, X., Kenner, L., Wagner, K.U., Mikulits, W., Kozlov, A.V., Heim, M.H., Gouilleux, F., Haybaeck, J., and Moriggl, R. (2016).
Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice. Sci Rep 6, 34719. doi: 10.1038/srep34719

Zotz, J.S., Wölbing, F., Lassnig, C., Kauffmann, M., Schulte, U., Kolb, A., Whitelaw, B., Müller, M., Biedermann, T., and Huber, M. (2016).
CD13/aminopeptidase N is a negative regulator of mast cell activation. FASEB J 2016 March 02. [Epub ahead of print] doi: 10.1096/fj.201600278.



Abdul-Sater, A.A., Majoros, A., Plumlee, C.R., Perry, S., Gu, A.D., Lee, C., Shresta, S., Decker, T., and Schindler, C. (2015).
Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs. J Immunol 195, 210-216.

Bakiri, L., Macho-Maschler, S., Custic, I., Niemiec, J., Guio-Carrion, A., Hasenfuss, S.C., Eger, A., Muller, M., Beug, H., and Wagner, E.F. (2015).
Fra-1/AP-1 induces mammary epithelial cell EMT by modulating Zeb1/2 and TGFbeta expression. Cell Death Differ 22, 336-350.

Bauer, E., Witalisz, A., Strobl, B., and Stoiber, D. (2015).
Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice. Methods Mol Biol 1267, 439-456. [review]

Berry, D., Kuzyk, O., Rauch, I., Heider, S., Schwab, C., Hainzl, E., Decker, T., Müller, M., Strobl, B., Schleper, C., Urich, T., Wagner, M., Kenner, L., and Loy, A. (2015).
Intestinal microbiota signatures associated with inflammation history in mice experiencing recurring colitis. Front Microbiol 6, 1408. doi: 10.3389/fmicb.2015.01408

Gilbert, S., Nivarthi, H., Mayhew, C.N., Lo, Y.H., Noah, T.K., Vallance, J., Rulicke, T., Muller, M., Jegga, A.G., Tang, W., Zhang, D., Helmrath, M., Shroyer, N., Moriggl, R., and Han, X. (2015).
Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration. Stem Cell Rep 4, 209-225.

Girardot, M., Pecquet, C., Chachoua, I., Van Hees, J., Guibert, S., Ferrant, A., Knoops, L., Baxter, E.J., Beer, P.A., Giraudier, S., Moriggl, R., Vainchenker, W., Green, A.R., and Constantinescu, S.N. (2015).
Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene 34, 1323-1332.

Hainzl, E., Stockinger, S., Rauch, I., Heider, S., Berry, D., Lassnig, C., Schwab, C., Rosebrock, F., Milinovich, G., Schlederer, M., Wagner, M., Schleper, C., Loy, A., Urich, T., Kenner, L., Han, X., Decker, T., Strobl, B., and Muller, M. (2015).
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis. J Immunol 195, 5011-5024. doi: 10.4049/jimmunol.1402565

Leitner, N.R., Witalisz-Siepracka, A., Strobl, B., and Müller, M. (2015).
Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene. Cytokine. 2015 Nov 26. pii: S1043-4666(15)30086-7. doi: 10.1016/j.cyto.2015.10.015. [Epub ahead of print] [review]

Meissl, K., Macho-Maschler, S., Müller, M., and Strobl, B. (2015).
The good, the bad and the unknown faces of STAT1 in carcinogenesis. Cytokine. 2015 Nov 26. pii: S1043-4666(15)30099-5. doi: 10.1016/j.cyto.2015.11.011. [Epub ahead of print] [review]

Merkel, O., Hamacher, F., Griessl, R., Grabner, L., Schiefer, A.I., Prutsch, N., Baer, C., Egger, G., Schlederer, M., William Krenn, P., Nicole Hartmann, T., Simonitsch-Klupp, I., Plass, C., Staber, P., Moriggl, R., Turner, S.D., Greil, R., and Kenner, L. (2015).
Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation. J Pathol 236, 445-456. doi: 10.1002/path.4539.

Minas, T.Z., Han, J., Javaheri, T., Hong, S.H., Schlederer, M., Saygideger-Kont, Y., Celik, H., Mueller, K.M., Temel, I., Ozdemirli, M., Kovar, H., Erkizan, H.V., Toretsky, J., Kenner, L., Moriggl, R., and Uren, A. (2015).
YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. Oncotarget 6, 37678-37694 DOI: 10.18632/oncotarget.5520

Nivarthi, H., Prchal-Murphy, M., Swoboda, A., Hager, M., Schlederer, M., Kenner, L., Tuckermann, J., Sexl, V., Moriggl, R., and Ermakova, O. (2015).
Stat5 gene dosage in T cells modulates CD8 T cell homeostasis and attenuates contact hypersensitivity response in mice. Allergy 70, 67-79.

Pathria, P., Gotthardt, D., Prchal-Murphy, M., Putz, E.M., Holcmann, M., Schlederer, M., Grabner, B., Crncec, I., Svinka, J., Musteanu, M., Hoffmann, T., Filipits, M., Berger, W., Poli, V., Kenner, L., Bilban, M., Casanova, E., Müller, M., Strobl, B., Bayer, E., Mohr, T., Sexl, V., and Eferl, R. (2015).
Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. Oncoimmunology 4, e998529.

Park, J., Schlederer, M., Schreiber, M., Ice, R., Merkel, O., Bilban, M., Hofbauer, S., Kim, S., Addison, J., Zou, J., Ji, C., Bunting, S.T., Wang, Z., Shoham, M., Huang, G., Bago-Horvath, Z., Gibson, L.F., Rojanasakul, Y., Remick, S., Ivanov, A., Pugacheva, E., Bunting, K.D., Moriggl, R., Kenner, L., and Tse, W. (2015).
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget 6, 20697-20710.

Pencik, J., Schlederer, M., Gruber, W., Unger, C., Walker, S.M., Chalaris, A., Marie, I.J., Hassler, M.R., Javaheri, T., Aksoy, O., Blayney, J.K., Prutsch, N., Skucha, A., Herac, M., Kramer, O.H., Mazal, P., Grebien, F., Egger, G., Poli, V., Mikulits, W., Eferl, R., Esterbauer, H., Kennedy, R., Fend, F., Scharpf, M., Braun, M., Perner, S., Levy, D.E., Malcolm, T., Turner, S.D., Haitel, A., Susani, M., Moazzami, A., Rose-John, S., Aberger, F., Merkel, O., Moriggl, R., Culig, Z., Dolznig, H., and Kenner, L. (2015).
STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun 6, 7736.

Prchal-Murphy, M., Witalisz-Siepracka, A., Bednarik, K.T., Putz, E.M., Gotthardt, D., Meissl, K., Sexl, V., Müller, M., and Strobl, B. (2015).
In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity. Oncoimmunology 4, e1047579 DOI: 10.1080/2162402X.2015.1047579

Rauch, I., Rosebrock, F., Hainzl, E., Heider, S., Majoros, A., Wienerroither, S., Strobl, B., Stockinger, S., Müller, M., Kenner, L., and Decker, T. (2015).
Noncanonical effects of IRF9 in intestinal inflammation: more than type I and type III interferons. Mol Cell Biol 35, 2332-2343.

Schneckenleithner, C., Hoelbl-Kovacic, A., and Sexl, V. (2015).
Modeling BCR/ABL-Driven Malignancies in the Mouse. Methods in Mol Biol 1267, 263-282. [review]

Schutz, A., Roser, K., Klitzsch, J., Lieder, F., Aberger, F., Gruber, W., Mueller, K.M., Pupyshev, A., Moriggl, R., and Friedrich, K. (2015).
Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation. Transl Oncol 8, 97-105.

Shukla, P., Vogl, C., Wallner, B., Rigler, D., Müller, M., and Macho-Maschler, S. (2015).
High-Throughput mRNA and miRNA Profiling of Epithelial-Mesenchymal Transition in MDCK cells. BMC Genomics 16, 944.

Stiedl, P., McMahon, R., Blaas, L., Stanek, V., Svinka, J., Grabner, B., Zollner, G., Kessler, S.M., Claudel, T., Muller, M., Mikulits, W., Bilban, M., Esterbauer, H., Eferl, R., Haybaeck, J., Trauner, M., and Casanova, E. (2015).
Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology 61, 613-626.

Them, N.C., Bagienski, K., Berg, T., Gisslinger, B., Schalling, M., Chen, D., Buxhofer-Ausch, V., Thaler, J., Schloegl, E., Gastl, G.A., Wolf, D., Strecker, K., Egle, A., Melchardt, T., Burgstaller, S., Willenbacher, E., Zagrijtschuk, O., Klade, C., Greil, R., Gisslinger, H., and Kralovics, R. (2015).
Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b. Am J Hematol 90, 288-294

Üstün, S., Lassnig, C., Preitschopf, A., Mikula, M., Müller, M., Hengstschläger, M., and Weichhart, T. (2015).
Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transpl Immunol 33, 45-50. doi: 10.1016/j.trim.2015.06.001.

Wienerroither, S., Shukla, P., Farlik, M., Majoros, A., Stych, B., Vogl, C., Cheon, H., Stark, G.R., Strobl, B., Müller, M., and Decker, T. (2015).
Cooperative transcriptional activation of antimicrobial genes by STAT and NFκB pathways through concerted recruitment of the mediator complex. Cell reports 12, 1-13. doi:10.1016/j.celrep.2015.06.021

Wiesauer, I., Gaumannmuller, C., Steinparzer, I., Strobl, B., and Kovarik, P. (2015).
Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription. Mol Cell Biol 35, 716-727.



Begitt, A., Droescher, M., Meyer, T., Schmid, C.D., Baker, M., Antunes, F., Owen, M.R., Naumann, R., Decker, T., and Vinkemeier, U. (2014).
STAT1-cooperative DNA binding distinguishes type-1 from type-2 interferon signaling. Nat Immunol 15, 168-176.

Berger, A., Hoelbl-Kovacic, A., Bourgeais, J., Hoefling, L., Warsch, W., Grundschober, E., Uras, I.Z., Menzl, I., Putz, E.M., Hoermann, G., Schuster, C., Fajmann, S., Leitner, E., Kubicek, S., Moriggl, R., Gouilleux, F., and Sexl, V. (2014).

PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28, 629-641.

Berger, A., Sexl, V., Valent, P., and Moriggl, R. (2014).
Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia. Oncotarget 5, 9564-9576.

Bibi, S., Arslanhan, M.D., Langenfeld, F., Jeanningros, S., Cerny-Reiterer, S., Hadzijusufovic, E., Tchertanov, L., Moriggl, R., Valent, P., and Arock, M. (2014).
Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy. Haematologica 99, 417-429. [review]

Bosmann, M., Russkamp, N.F., Strobl, B., Roewe, J., Balouzian, L., Pache, F., Radsak, M.P., van Rooijen, N., Zetoune, F.S., Sarma, J.V., Núnez, G., Müller, M., Murray, P.J., and Ward, P.A. (2014).
Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J Immunol 193, 5668-5677.

Bosmann, M., Strobl, B., Kichler, N., Pache, F., Murray, P.J., Müller, M., and Ward, P.A. (2014).
Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol. 96, 123-131.

Csiszar, A., Kutay, B., Wirth, S., Schmidt, U., Macho-Maschler, S., Schreiber, M., Alacakaptan, M., Vogel, G.F., Aumayr, K., Huber, L.A., and Beug, H. (2014).
Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen inverted question mark urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Breast Cancer Res 16, 433.

Gotthardt, D., Putz, E.M., Straka, E., Kudweis, P., Biaggio, M., Poli, V., Strobl, B., Muller, M., and Sexl, V. (2014).
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood 124, 2370-2379.

Gotthardt, D., Prchal-Murphy, M., Seillet, C., Glasner, A., Mandelboim, O., Carotta, S., Sexl, V., and Putz, E.M. (2014)
NK cell development in bone marrow and liver: site matters. Genes Immun 15, 584-587.

Grundschober, E., Hoelbl-Kovacic, A., Bhagwat, N., Kovacic, B., Scheicher, R., Eckelhart, E., Kollmann, K., Keller, M., Grebien, F., Wagner, K.U., Levine, R.L., and Sexl, V. (2014).
Acceleration of Bcr-Abl leukemia induced by deletion of JAK2. Leukemia 28, 1918-1922.

Grunert, T., Monahan, A., Lassnig, C., Vogl, C., Strobl, B., Müller, M., and Ehling-Schulz, M. (2014).
Deciphering host genotype-specific impacts on the metabolic fingerprint of Listeria monocytogenes by FTIR spectroscopy. PLoS One 9, e115959.

Jager, R., Harutyunyan, A.S., Rumi, E., Pietra, D., Berg, T., Olcaydu, D., Houlston, R.S., Cazzola, M., and Kralovics, R. (2014).
Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms. Am J Hematol 89, 1107-1110.

Keil, E., Finkenstädt, D., Wufka, C., Trilling, M., Liebfried, P., Strobl, B., Müller, M., and Pfeffer, K. (2014).
Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation loop mutation. Blood 123, 520-529.

Klose, C.S., Flach, M., Mohle, L., Rogell, L., Hoyler, T., Ebert, K., Fabiunke, C., Pfeifer, D., Sexl, V., Fonseca-Pereira, D., Domingues, R.G., Veiga-Fernandes, H., Arnold, S.J., Busslinger, M., Dunay, I.R., Tanriver, Y., and Diefenbach, A. (2014).
Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages. Cell 157, 340-356.

Kovacic, B., Hoelbl-Kovacic, A., Fischhuber, K.M., Leitner, N.R., Gotthardt, D., Casanova, E., Sexl, V., and Muller, M. (2014).
Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells. Haematologica 99, 1006-1015.

Leitner, N.R., Lassnig, C., Rom, R., Heider, S., Bago-Horvath, Z., Eferl, R., Müller, S., Kolbe, T., Kenner, L., Rülicke, T., Strobl, B., and Müller, M. (2014).
Inducible, dose-adjustable and time-restricted reconstitution of Stat1 deficiency in vivo. PLoS One 9, e86608.

Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K.K., Carret, C., Lassnig, C., Müller, M., Kalinke, U., Saeed, M., Ferreira Chora, A., Golenbock, D.T., Strobl, B., Prudencio, M., Coelho, L.P., Kappe, S.H., Superti-Furga, J., Pichlmair, A., Vigário, A.M., Rice, C.M., Fitzgerald, K.A., Barchert, W., and Mota, M.M. (2014).
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20: 47-53.

Putz, E.M., Hoelzl, M.A., Baeck, J., Bago-Horvath, Z., Schuster, C., Reichholf, B., Kern, D., Aberger, F., Sexl, V., and Hoelbl-Kovacic, A. (2014).
Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance. Cancers 6, 193-210.

Schlederer, M., Mueller, K.M., Haybaeck, J., Heider, S., Huttary, N., Rosner, M., Hengstschlager, M., Moriggl, R., Dolznig, H., and Kenner, L. (2014).
Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections. PLoS One 9, e100822.

Semper, C., Leitner, N.R., Lassnig, C., Parrini, M., Mahlakoiv, T., Rammerstorfer, M., Lorenz, K., Rigler, D., Müller, S., Kolbe, T., Vogl, C., Rülicke, T., Staeheli, P., Decker, T., Müller, M., and Strobl, B. (2014).
STAT1β is not dominant negative and is capable of contributing to IFNγ-dependent innate immunity. Mol Cell Biol 34, 2235-2248.

Strobl, B., and Moriggl, R. (2014).
Editorial: Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis. J Leukocyte Biol 95, 849-851. [editorial review]

Vielnascher, R.M., Hainzl, E., Leitner, N.R., Rammerstorfer, M., Popp, D., Witalisz, A., Rom, R., Karaghiosoff, M., Kolbe, T., Müller, S., Rülicke, T., Lassnig, C., Strobl, B., and Müller, M. (2014).
Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res. 23, 519-529

Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, A.M., Bradner, J., Muhar, M., Zuber, J., Müller, M., and Decker, T. (2014).
Regulation of NO synthesis, local inflammation and innate immunity to pathogens by BET family proteins. Mol Cell Biol 34, 415-427.



Bancerek, J., Poss, Z.C., Steinparzer, I., Sedlyarov, V., Pfaffenwimmer, T., Mikulic, I., Dölken, L., Strobl, B., Müller, M., Taatjes, D.J., and Kovarik, P. (2013).
CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity 38, 250-262.

Chatain, N., Ziegler, P., Fahrenkamp, D., Jost, E., Moriggl, R., Schmitz-Van de Leur, H., and Müller-Newen, G. (2013).
Scr family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene 32, 3587-3597.

Gordziel, C., Bratsch, J., Moriggl, R., Knosel, T. and Friedrich. K. (2013).
Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br J Cancer 109, 138-146

Hannesdottir, L., Tymoszuk, P., Parajuli, N., Wasmer, M.H., Philipp, S., Daschil, N., Datta, S., Koller, J.B., Tripp, C.H., Stoitzner, P., Muller-Holzner, E., Wiegers, G.J., Sexl, V., Villunger, A., and Doppler, W. (2013).
Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. 43, 2718-2729.

Kantner, H.P., Warsch, W., Delogu, A., Bauer, E., Esterbauer, H., Casanova, E., Sexl, V., and Stoiber, D. (2013).
ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells. Neoplasia 15, 1292-1300.

Katholnig, K., Kaltenecker, C.C., Hayakawa, H., Rosner, M., Lassnig, C., Zlabinger, G.J., Gaesetl, M., Müller, M., Hengstschläger, M., Hörl, W.H., Park, J.-M., Säemann, M.D., and Weichart, T. (2013).
p38α Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin. J Immunol 190, 1519-1527.

Kernbauer, E., Maier, V., Rauch, I., Müller, M. and Decker, T. (2013).
Route of infection determines the impact of type I interferons on innate immunity to Listeria monocytogenes. PLoS One 8: e65007.

Kollmann, K., Heller, G., Schneckenleitner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., LKenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M., and Sexl, V. (2013).
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis. Cancer Cell 24, 167-181.

Koromilas, A.E., and Sexl, V. (2013).
The tumor suppressor function of STAT1 in breast cancer. JAK-STAT 2:2, 1-5. dx.doi.org/10.4161/jkst.23353 [review]

Köprülü, A.D., Kastner, R., Wienerroither, S., Lassnig, C., Putz, E.-M., Majer, O., Reutterer, B., Sexl, V., Kuchler, K., Müller, M., Decker, T., and Ellmeier, W. (2013).
The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PLoS One 8, e60476.

McGuckin, C.P., Jurga, M., Miller, A.M., Sarnowska, A., Wiedner, M., Boyle, N.T., Lynch, M.A., Jablonska, A., Drela, K., Lukomska, B., Domanska-Janik, K., Kenner, L., Moriggl, R., Degoul, O., Perruisseau-Carrier, C., and Forraz, N. (2013).
Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction. Arch Biochem Biophys. 534, 88-97

Putz, E.M., Gotthardt, D., Hoermann, G., Csiszar, A., Wirth, S., Berger, A., Straka, E., Rigler, D., Wallner, B., Jamieson, A.M., Pickl, W.F., Zebedin-Brandl, E.M., Muller, M., Decker, T., and Sexl, V. (2013).
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance. Cell Rep 15: 437-444

Rauch, I., Müller, M., and Decker, T. (2013).
The regulation of inflammation by interferons and their STATs. JAK-STAT 2:1, e23820. dx.doi.org/10.4161/jkst.23820 [review]

Richter, K., Perriard, G., Behrendt, R., Schwendener, R.A., Sexl, V., Dunn, R., Kamanaka, M., Flavell, R.A., Roers, A., and Oxenius, A. (2013).
Macrophage and T cell produced IL-10 promotes vrial chronicity. PLoS Pathog 9, e1003735.

Sanda, T., Tyner, J.W., Gutierrez, A., Ngo, V.N., Glover, J., Chang, B.H., Yost, A., Ma, W., Fleischman, A.G., Zhou, W., Yang, Y., Kleppe, M., Ahn, Y., Tatarek, J., Kelliher, M., Neuberg, D., Levine, R.L., Moriggl, R., Müller, M., Gray, N.S., Jamieson, C.H., Weng, A.P., Staudt, L.M., Druker, B.J., and Look, A.T. (2013).
TYK2-STAT1-BCL2 Pathway Dependence in T-Cell Acute Lymphoblastic Leukemia. Cancer Discov 3, 564-577.

Warsch, W., Grundschober, E., and Sexl, V. (2013).
Adding a new facet to STAT5 in CML: Multitasking for leukemic cells. Cell Cycle 12, 1813-1814. [editorial feature]

Warsch, W., Walz, C., and Sexl, V. (2013).
JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia. Blood 122, 2167-2175.

Warszawska, J.M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., Fuhrmann, V., Strobl, B., Müller, M., Schenk, P., Weiss, G., and Knapp, S. (2013).
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest 123, 3363-3372.



Allegra, M., Zaragkoulias, A., Vorgia, E., Ioannou, M., Litos, G., Beug, H., and Mavrothalassitis, G. (2012).
Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells. Mol Biol Cell 23, 3873-3881.

Aubry, C., Corr, S.C., Wienerroither, S., Goulard, C., Jones, R., Jamieson, A.M., Decker, T., O'Neill, L.A., Dussurget, O., and Cossart, P. (2012).
Both TLR2 and TRIF Contribute to Interferon-beta Production during Listeria Infection. PLoS One 7, e33299.

Decker, T., and Müller, M., eds. (2012).
Jak-Stat Signaling : From Basics to Disease (Vienna: Springer Vienna). doi: 10.1007/978-3-7091-0891-8 [edited book]

Decker, T., and Müller, M. (2012).
The Continuing Fascination with Jaks and Stats: An Introduction. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 1-4. doi: 10.1007/978-3-7091-0891-8_1 [book chapter]

Derecka, M., Gornicka, A., Koralov, S.B., Szczepanek, K., Morgan, M., Raje, V., Sisler, J., Zhang, Q., Otero, D., Cichy, J., Rajewsky, K., Shimoda, K., Poli, V., Strobl, B., Pellegini, S., Harris, T.E., Seale, P., Russell, A.P., McAinch, A.J., O'Brien, P.E., Keller, S., Croniger, C.M., Kordula, T., and Larner, A.C. (2012).
Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity. Cell Metab 16, 814-824.

Farlik, M., Rapp, B., Marie, I., Levy, D.E., Jamieson, A.M., and Decker, T. (2012).
Contribution of a TBK1-IRF7 pathway to IFN-gamma-induced gene expression. Mol Cell Biol 32, 1032-1043.

Friedbichler, K., Themanns, M., Mueller, K.M., Schlederer, M., Kornfeld, J.-W., Terracciano, L.M., Kozlov, A.V., Haindl, S., Kenner, L., Kolbe, T., Mueller, M., Snibson, K., Heim, M.H., and Moriggl, R. (2012).
Growth hormone-induced STAT5 signaling causes gigantism, inflammation and premature death but protects mice from aggressive liver cancer. Hepatology 55, 941-952.

Gilbert, S., Zhang, R., Denson, L., Moriggl, R., Steinbrecher, K., Shroyer, N., Lin, J., and Han, X. (2012).
Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med 4, 109-124.

Hantschel, O., Warsch, W., Eckelhart, E., Kaupe, I., Grebien, F., Wagner, K.U., Superti-Furga, G., and Sexl, V. (2012).
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol 8, 285-293

Jamieson, A.M., Farlik, M., and Decker, T. (2012).
How Stats Interact with the Molecular Machinery of Transcriptional Activation. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 65-89. doi: 10.1007/978-3-7091-0891-8_5 [book chapter]

Kernbauer, L., Maier, V., Stoiber, D., Strobl, B., Schneckenleithner, C., Sexl, V., Reichart, U., Kalinke, U., Reizis, B., Jamieson, A., Müller, M., and Decker, T. (2012).
Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection. PLoS Pathog 8, e1002763.

Kovacic, B., Hoelbl, A., Litos, G., Alacakaptan, M., Schuster, C., Fischhuber, K.M., Kerenyi, M.A., Stengl, G., Moriggl, R., Sexl, V., and Beug, H. (2012).
Diverging fates of cells of origin in acute and chronic leukaemia. EMBO Mol Med 4, 283-297.

Laimer, D., Dolznig, H., Kollmann, K., Vesely, P.W., Schlederer, M., Merkel, O., Schiefer, A.-I., Hassler, M.R., Heider, S., Amenitsch, L., Thallinger, C., Staber, P.B., Simonitsch-Klupp, I., Artaker, M., Lagger, S., Pileri, S., Piccaluga, P.P., Valent, P., Messana, K., Landra, I., Weichhart, T., Knapp, S., Shehata, M., Todaro, M., Sexl, V., Höfler, G., Piva, R., Medico, E., Riggeri, B.A., Cheng, M., Eferl, R., Egger, G., Penninger, J.M., Jaeger, U., Moriggl, R., Inghirami, G., and Kenner, L. (2012).
PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas. Nat Med 18, 1699-1704.

Majer, O., Bourgeois, C., Zwolanek, F., Lassnig, C., Kerjaschiki, D., Mack, M., Müller, M., and Kuchler, K. (2012).
Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections. PLoS Pathog 8, e1002811.

Mizutani, T., Neugebauer, N., Putz, E.M., Moritz, N., Simma, O., Zebedin-Brandl, E., Gotthardt, D., Warsch, W., Eckelhart, E., Kantner, H.-P., Kalinke, U., Lienenklaus, S., Weiss, S., Strobl, B., Müller, M., Sexl, V., and Stoiber, D. (2012).
Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1, 1027-1037.

Mueller, K.M., Themanns, M., Friedbichler, K., Kornfeld, J.W., Esterbauer, H., Tuckermann, J.P., and Moriggl, R. (2012).

Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol 361, 1-11.

Musteanu, M., Blaas, L., Zenz, R., Svinka, J., Hoffmann, T., Grabner, B., Schramek, D., Kantner, H.P., Müller, M., Kolbe, T., Rülicke, T., Moriggl, R., Kenner, L., Stoiber, D., Penninger, J., Popper, H., Casanova, E., and Eferl, R. (2012).
A mouse model to identify cooperating signaling pathways in cancer. Nat Methods 9, 897-900.

Nivarthi, H., Friedbichler, K., and Moriggl, R. (2012).
Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 153-167. doi: 10.1007/978-3-7091-0891-8_10 [book chapter]

Petz, M., Them, N., Huber, H., Beug, H., and Mikulits, W. (2012).
La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition. Nucleic Acids Res 40, 290-302.

Petz, M., Them, N.C., Huber, H., and Mikulits, W. (2012).
PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res 40, 9738-9749.

Prchal-Murphy, M., Semper, C., Lassnig, C., Wallner, B., Gausterer, C., Teppner-Klymiuk, I., Kobolak, J., Müller, S., Kolbe, T., Karaghiosoff, M., Dinnyes, A., Rülicke, T., Leitner, N.R., Strobl, B., and Müller, M. (2012).
TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo. PLoS One 7, e39141.

Putz, E.M., Prchal-Murphy, M., Simma, O.A., Forster, F., Koenig, X., Stockinger, H., Piekorz, R.P., Freissmuth, M., Müller, M., Sexl, V., and Zebedin-Brandl, E. (2012).
PI3Kδ Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes. PLoS One 7, e40852.

Putz, E.M., Zebedin, E., and Sexl, V. (2012).
STAT Transcription Factors: Controlling All Aspects of NK Cell Biology. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 187-204. doi: 10.1007/978-3-7091-0891-8_12 [book chapter]

Rampetsreiter, P., and Eferl, R. (2012).
STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 289-304. doi: 10.1007/978-3-7091-0891-8_16 [book chapter]

Rohr-Udilova, N., Sieghart, W., Eferl, R., Stoiber, D., Bjorkhem-Bergman, L., L, C.E., Stolze, K., Hayden, H., Keppler, B., Sagmeister, S., Grasl-Kraupp, B., Schulte-Hermann, R., and Peck-Radosavljevic, M. (2012).

Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma. Hepatology 55, 1112-1121.

Strobl, B., Leitner, R.N., and Müller, M. (2012).
Multifaceted Antiviral Actions of Interferon-stimulated Gene Products. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 387-423. doi: 10.1007/978-3-7091-0891-8_21 [book chapter]

Vogl, C., Shukla, P., and Ebersberger, I. (2012).
Evolution of Jak and Stat Proteins. In Jak-Stat Signaling: From Basics to Disease, T. Decker, and M. Müller, eds. (Vienna: Springer Vienna), pp. 99-114. doi: 10.1007/978-3-7091-0891-8_7 [book chapter]

Wallner, B., Leitner, N.R., Vielnascher, R.M., Kernbauer, E., Kolbe, T., Karaghiosoff, M., Rülicke, T., Decker, T., and Müller, M. (2012).
Generation of mice with a conditional Stat1 null allele. Transgenic Res 21, 217-224.

Warsch, W., Grundschober, E., Berger, A., Gille, L., Cerny-Reiterer, S., Tigan, A.-S., Hoelbl-Kovacic, A., Valent, P., Moriggl, R., and Sexl, V. (2012).
STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia. Oncotarget 3, 1669-1687.




Blanc, M., Hsieh, W., Robertson, K., Watterson, S., Shui, G., Lacaze, P., Khondoker, M., Dickinson, P., Sing, G., Rodriguez-Martin, S., Phelan, P., Forster, T., Strobl, B., Müller, M., Riemersma, R., Osborne, T., Wenk, M.R., Angulo, A., and Ghazal, P. (2011).
Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol 9, e1000598.

Bourgeois, C., Majer, O., Frohner, I.E., Lesiak-Markowicz, I., Kwang-Soo, H., Glaser, W., Stockinger, S., Decker, T., Akira, S., Müller, M., and Kuchler, K. (2011).
Conventional dendritic cells mount a type I interferone response against Candida spp requiring novel phagosomal TLR7 mediated IFN-β signaling. J Immunol 186, 3104 - 3112.

Eckelhart, E., Warsch, W., Zebedin, E., Simma, O., Stoiber, D., Kolbe, T., Rulicke, T., Mueller, M., Casanova, E., and Sexl, V. (2011).
A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK cell survival and development. Blood 117, 1565-1573.

Ermakova, O., Piszczek, L., Luciani, L., Cavalli, F.M., Ferreira, T., Farley, D., Rizzo, S., Paolicelli, R.C., Al-Banchaabouchi, M., Nerlov, C., Moriggl, R., Luscombe, N. M., and Gross, C. (2011).
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med 3, 50-66.

Ferbeyre, G., and Moriggl, R. (2011).
The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 1815, 104-114. (review)

Friedbichler, K., Hoelbl, A., Li, G., Bunting, K.D., Sexl, V., Gouilleux, F., and Moriggl, R. (2011).
Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation. Front Biosci 17, 3043-3056. (review)

Gratz, N., Hartweger, H., Matt, U., Kratochwill, F., Janos, M., Sigel, S., Drobits, B., Li, X.-D., Knapp, S., and Kovarik, P. (2011).
Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection. PLoS Pathog 7, e1001345.

Grunert, T., Marchett-Deschmann, M., Miller, I., Leitner, N.R., Wallner, B., Radwan, M., Vogl, C., Kobe, T., Kratky, D., Gemeiner, M., Allmaier, G., Müller, M. and Strobl, B. (2011).
A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C). J Proteomics 74, 2866 - 2880

Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zochbauer-Muller, S., Malumbres, M., and Sexl, V. (2011).
C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood 117, 4065 - 4075.

Kornfeld, J.W., Isaacs, A., Vitart, V., Pospisilik, J.A., Meitinger, T., Gyllensten, U., Wilson, J.F., Rudan, I., Campbell, H., Penninger, J.M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P. P., and Hicks, A. A. (2011).
Variants in STAT5B Associate with Serum TC and LDL-C Levels. J Clin Endocrinol Metab. 96, E1496-501

Kratochvill, F., Machacek, C., Vogl, C., Ebner, F., Sedlyarov, V., Gruber, A.R., Hartweger, H., Vielnascher, R., Karaghiosoff, M., Rülicke, T., Müller, M., Hofacker, I., Lang, R., and Kovarik, P. (2011).
Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Mol Sys Biol 7, 560.

Kropp, K.A., Robertson, K.A., Sing, G., Rodriguez-Martin, S., Blanc, M., Lacaze, P., Noor Hassim, M.F.B., Khondoker, M.R., Busche, A., Dickinson, P., Forster, T., Strobl, B., Müller, M., Jonjic, S., Angulo, A., Ghazal, P. (2011).
Reversible inhibition of MCMV replication by IFN{gamma} in primary macrophages involves a primed type I IFN signaling sub-network for full establishment of an immediate-early antiviral-state. J Virol 85, 10286 - 10299

Mair, M., Blaas, L., Osterreicher, C.H., Casanova, E., and Eferl, R. (2011).
JAK-STAT signaling in hepatic fibrosis. Front Biosci 17, 2794-2811. (review)

Mueller, K.M., Kornfeld, J.W., Friedbichler, K., Blaas, L., Egger, G., Esterbauer, H., Hasselblatt, P., Schlederer, M., Haindl, S., Wagner, K.U., Engblom, D., Haemmerle, G., Kratky, D., Sexl, V., Kenner, L., Kozlov, A. V., Terracciano, L., Zechner, R., Schuetz, G., Casanova, E., Pospisilik, J. A., Heim, M. H., and Moriggl, R. (2011).
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology 54, 1398 - 1409

Pichlmair, A., Lassnig, C., Eberle, C.-A., Górna, M.W., Baumann, C.L., Burkard, T.R., Bürckstümmer, T., Stefanovic, A., Krieger, S., Bennet, K.L., Rülicke, T., Weber, F., Colinge, J., Müller, M., and Superti-Furga, G. (2011).
IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA. Nat Immunol. 12, 624-630.

Rampetsreiter, P., Casanove, E., and Eferl, R. (2011).
Genetically modified mouse models of cancer invasion and metastasis. Drug Discov Today 8, 67-74. (review)

Roetzer, A., Klopf, E., Gratz, N., Marcet-Houben, M., Hiller, E., Rupp, S., Gabaldon, T., Kovarik, P., and Schuller, C. (2011).
Regulation of Candida glabrata oxidative stress resistance is adapted to host environment. FEBS Lett 585, 319-327.

Schneckenleithner, C., Bago-Horvath, Z., Dolznig, H., Neugebauer, N., Kollmann, K., Kolbe, T., Decker, T., Kerjaschki, D., Wagner, K.-U., Müller, M., Stoiber, D., and Sexl, V. (2011).
Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget 2, 1043-1054

Schneller, D., Machat, G., Sousek, A., Proell, V., van Zijl, F., Zulehner, G., Huber, H., Mair, M., Muellner, M.K., Nijman, S.M., Eferl, R., Moriggl, R., Mikulits, W. (2011).
p19(ARF) /p14(ARF) controls oncogenic functions of Stat3 in hepatocellular carcinoma. Hepatology 54, 164-172

Schuster, C., Berger, A., Hoelzl, M.A., Putz, E.M., Frenzel, A., Simma, O., Moritz, N., Hoelbl, A., Kovacic, B., Freissmuth, M., Muller, M., Villunger, A., Mullauer, L., Schmatz, A. I., Porpaczy, E., Jager, U., Stoiber, D., and Sexl, V. (2011).
The cooperating mutation or "second hit" determines the immunological visibility towards MYC-induced murine lymphomas. Blood 118, 4635 - 4645

Strobl, B., Stoiber, D., Sexl, V., and Müller, M. (2011).
Tyrosine kinase 2 (Tyk2) in cytokine signalling and host immunity. Front Biosci 17, 3224-3232. (review)

Todoric, J., Strobl, B., Jais, A., Boucheron, N., Bayer, M., Amann, S., Lindroos, J., Teperino, R., Prager, G., Bilban, M., Ellmeier, W., Krempler, F., Muller, M., Wagner, O., Patsch, W., Pospisilik, J. A. and Esterbauer, H. (2011).
Cross-Talk Between Interferon-{gamma} and Hedgehog Signaling Regulates Adipogenesis. Diabetes 60, 1668-76.

van Zijl, F., Krupitza, G., and Mikulits, W. (2011).
Initial steps of metastasis: Cell invasion and endothelial transmigration. Mutat Res. 728: 23-34; doi:10.1016/j.mrrev.2011.05.002 (review)

van Zijl, F., Mall, S., Machat, G., Pirker, C., Zeilinger, R., Weinhaeusel, A., Bilban, M., Berger, W., and Mikulits, W. (2011).
A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression. Mol Cancer Ther 10, 850-860.

Warsch, W., Kollmann, K., Eckelhart, E., Fajmann, S., Cerny-Reiterer, S., Holbl, A., Gleixner, K.V., Dworzak, M., Mayerhofer, M., Hoermann, G., Herrmann, H., Sillaber, C., Egger, G., Valent, P., Moriggl, R., and Sexl, V. (2011).
High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood 117, 3409 - 3420.

Weichhart, T., Haidinger, M., Katholnig, K., Kopecky, C., Poglitsch, M., Lassnig, C., Rosner, M., Zlabinger, G.J., Hengstschläger, M., Müller, M., Hörl, W.H., and Säemann, M.D. (2011).
Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 117, 4273 - 4283.




Beer-Hammer, S., Zebedin, E., von Holleben, M., Alferink, J., Reis, B., Dresing, P., Degrandi, D., Scheu, S., Hirsch, E., Sexl, V., Pfeffer, K., Nurnberg, B., and Piekorz, R. P. (2010)
The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation. J Leukoc Biol 87, 1083-1095.

Blaas, L., Kornfeld, J.W., Schramek, D., Musteanu, M., Zollner, G., Gumhold, J., van Zijl, F., Schneller, D., Esterbauer, H., Egger, G., Mair, M., Kenner, L., Mikulits, W., Eferl, R., Moriggl, R., Penninger, J., Trauner, M., and Casanova, E. (2010)
Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology 51, 1319-1326.

Creamer, B.A., Sakamoto, K., Schmidt, J.W., Triplett, A.A., Moriggl, R., and Wagner, K.U. (2010)
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol 30, 2957-2970.

Farlik, M., Reutterer, B., Schindler, C., Greten, F., Vogl, C., Muller, M., and Decker, T. (2010)
Nonconventional Initiation Complex Assembly by STAT and NF-kappaB Transcription Factors Regulates Nitric Oxide Synthase Expression. Immunity 33, 25-34.

Friedbichler, K., Kerenyi, M.A., Kovacic, B., Li, G., Hoelbl, A., Yahiaoui, S., Sexl, V., Mullner, E.W., Fajmann, S., Cerny-Reiterer, S., Valent, P., Beug, H., Gouilleux, F., Bunting, K. D., and Moriggl, R.(2010).
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood 116, 1548-1558.

Grusch, M., Petz, M., Metzner, T., Ozturk, D., Schneller, D., and Mikulits, W. (2010)
The crosstalk of RAS with the TGF-beta family during carcinoma progression and its implications for targeted cancer therapy. Curr Cancer Drug Targets 10, 849-857. (review)

Hoelbl, A., Schuster, C., Kovacic, B., Zhu, B., Wickre, M., Hoelzl, M.A., Fajmann, S., Grebien, F., Warsch, W., Stengl, G., Hennighausen, L., Poli, V., Beug, H., Moriggl, R., and Sexl, V. (2010)
Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med 2, 98-110.

Hofmann, E., Reichart, U., Gausterer, C., Gülly, C., Meijer, D., Müller, M., and Strobl, B. (2010)
Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses. BMC Cell Biol 11, 61.

Khan, M., Giessrigl, B., Vonach, C., Madlener, S., Prinz, S., Herbaceck, I., Holzl, C., Bauer, S., Viola, K., Mikulits, W., Quereshi, R. A., Knasmuller, S., Grusch, M., Kopp, B., Krupitza, G. (2010)
Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mutat Res 683, 123-130.

Li, G., Miskimen, K.L., Wang, Z., Xie, X.Y., Brenzovich, J., Ryan, J.J., Tse, W., Moriggl, R., and Bunting, K.D. (2010)
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. Blood 115, 1416-1424.

Li, G., Miskimen, K.L., Wang, Z., Xie, X.Y., Tse, W., Gouilleux, F., Moriggl, R., and Bunting, K.D. (2010).
Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin. Leukemia 24, 1397-1405.

Madlener, S., Saiko, P., Vonach, C., Viola, K., Huttary, N., Stark, N., Popescu, R., Gridling, M., Vo, N.T., Herbacek, I., Davidovits, A., Giessrigl, B., Venkateswarlu, S., Geleff, S., Jager, W., Grusch, M., Kerjaschki, D., Mikulits, W., Golakoti, T., Fritzer-Szekeres, M., Szekeres, T., and Krupitza, G. (2010)
Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro. Br J Cancer 102, 1361-1370.

Maier, H.J., Schmidt-Strassburger, U., Huber, M.A., Wiedemann, E.M., Beug, H., and Wirth, T. (2010)
NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 295, 214-228.

Mair, M., Zollner, G., Schneller, D., Musteanu, M., Fickert, P., Gumhold, J., Schuster, C., Fuchsbichler, A., Bilban, M., Tauber, S., Esterbauer, H., Kenner, L., Poli, V., Blaas, L., Kornfeld, J. W., Casanova, E., Mikulits, W., Trauner, M., Eferl, R. (2010)
Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology 138, 2499-2508.

Maschler, S., Gebeshuber, C.A., Wiedemann, E.M., Alacakaptan, M., Schreiber, M., Custic, I., and Beug, H. (2010).
Annexin A1 attenuates EMT and metastatic potential in breast cancer. EMBO Mol Med 2, 401-414.

Musteanu, M., Blaas, L., Mair, M., Schlederer, M., Bilban, M., Tauber, S., Esterbauer, H., Mueller, M., Casanova, E., Kenner, L., Poli, V. and Eferl, R. (2010)
Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology 138, 1003-1011 e1001-1005.

Radwan, M., Stiefvater, R., Grunert, T., Sharif, O., Miller, I., Marchetti-Deschmann, M., Allmaier, G., Gemeiner, M., Knapp, S., Kovarik, P., Müller, M., and Strobl, B. (2010)
Tyrosine kinase 2 controls IL-1beta production at the translational level. J Immunol 185, 3544-3553.

Roetzer, A., Gratz, N., Kovarik, P., and Schuller, C. (2010)
Autophagy supports Candida glabrata survival during phagocytosis. Cell Microbiol 12, 199-216.

van Zijl, F., and Mikulits, W. (2010)
Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver. World J Hepatol 2, 1-7. (review)

Vogl, C., Flatt, T., Fuhrmann, B., Hofmann, E., Wallner, B., Stiefvater, R., Kovarik, P., Strobl, B., and Muller, M. (2010)
Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes. BMC Genomics 11, 199.

Zulehner, G., Mikula, M., Schneller, D., van Zijl, F., Huber, H., Sieghart, W., Grasl-Kraupp, B., Waldhor, T., Peck-Radosavljevic, M., Beug, H., and Mikulits, W. (2010)
Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am J Pathol 176, 472-481.




Aly, S., Mages, J., Reiling, N., Kalinke, U., Decker, T., Lang, R. and Ehlers, S. (2009).
Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13(8B):2069-82.

Baumgartner, C., Sonneck, K., Mayerhofer, M., Gleixner, K., Fritz, R., Cerny-Reiterer, S., Kerenyi, M., Kornfeld, J.W., Sillaber, C., Moriggl, R. and Valent, P. (2009).
Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V. American J Pathol 75(6):2416-29.

Blaas, L., Musteanu, M., Eferl, R., Bauer, A. and Casanova, E. (2009).
Bacterial artificial chromosomes improve recombinant protein production in mammalian cells. BMC Biotechnol 9:3.

Ecker, A., Simma, O., Hoelbl, A., Kenner, L., Beug, H., Moriggl, R., and Sexl, V. (2009).
The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor. Front Biosci 14, 2944-2958. (review)

Fialka-Moser, V., Fonatsch, C., Jensen-Jarolim, E., Koppensteiner, R., Lang, I., Mannhalter, C., Pabinger, I., Pavelka, M., Piehslinger, E., Rieder, A., Schmid-Erfurth, U., Sexl, V., Sibilia, M., Springer-Kremser, M. and Wiedermann, U.
The club of female professors of the Medical University of Vienna (2009). Wien Med Wochensch 159:95-109. (comment)

Friedbichler, K., Kerenyi, M.A., Müllner, E.W., and Moriggl, R. (2009).
Stat5 as Hematopoietic Gatekeeper and Oncogene Upon Tyrosine Kinase‑Induced Transformation. In JAK-STAT Pathway in Disease, A. Stephanou, ed. (Austin Texas USA: Landes Bioscience), pp. 131-150. URL: www.researchgate.net/publication/224902343_Stat5_as_hematopoietic_gatekeeper_and_oncogene_upon_tyrosine_kinase-induced_transformation [book chapter]

Grundtner, P., Gruber, S., Murray, S.S., Vermeire, S., Rutgeerts, P., Decker, T., Lakatos, P.L. and Gasche, C. (2009).
The IL10R1 S138G loss-of-function allele and ulcerative colitis. Genes Immun 10:84-92.

Lahsnig, C., Mikula, M., Petz, M., Zulehner, G., Schneller, D., van Zijl, F., Huber, H., Csiszar, A., Beug, H. and Mikulits, W. (2009).
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 28:638-50.

Macheiner D, Gauglhofer C, Rodgarkia-Dara C, Grusch M, Brachner A, Bichler C, Kandioler D, Sutterlüty H, Mikulits W, Schulte-Hermann R, Grasl-Kraupp B (2009)
NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A. Cancer Research 69, 235-242.

Maldonado, R.A., Soriano, M.A., Perdomo, C., Sigrist, K., Irvine, D.J., Decker, T. and Glimcher, L.H. (2009).
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med 206(4):877-92.

Pflegerl, P., Vesely, P., Hantusch, B., Schlederer, M., Zenz, R., Janig, E., Steiner, G., Meixner, A., Petzelbauer, P., Wolf, P., Soleiman, A., Egger, G., Moriggl, R., Kishimoto, T., Wagner, E.F., and Kenner, L. (2009).
Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci U S A 106, 20423-20428.

Pilz, A., Kratky, W., Stockinger, S., Simma, O., Kalinke, U., Lingnau, K., von Gabain, A., Stoiber, D., Sexl, V., Kolbe, T., Rulicke, T., Müller, M. and Decker, T. (2009).
Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183:2286-93.

Plumlee, C.R., Lee, C., Song, L., Prince, A., Beg, A., Decker, T., Shuman, H.A. and. Schindler, C. (2009).
Interferons direct an effective innate response to Legionella pneumophila infection. J Biol Chem 284(44):30058-66.

Prchal, M., Pilz, A., Simma, O., Lingnau, K., von Gabain, A., Müller, M., Strobl, B., and Decker, T. (2009)
Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity. Vaccine 27 Suppl 6, G17-20.

Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Müller, M., Blackshear, P.J., Poli, V., Lang, R., Murray, P.J. and Kovarik, P. (2009).
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183:1197-206.

Schnidar, H., Eberl, M., Klingler, S., Mangelberger, D., Kasper, M., Hauser-Kronberger, C., Regl, G., Kroismayr, R., Moriggl, R., Sibilia, M. and Aberger, F. (2009).
Epidermal growth factor receptor signaling synergizes with hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res 69:1284-92.

Simma O, Zebedin E, Neugebauer N, Schellack C, Pilz A, Chang-Rodriguez S, Lingnau K, Weisz E, Putz EM, Pickl WF, Felzmann T, Müller M, Decker T, Sexl V, Stoiber D (2009)
Identification of an indispensable role for Tyk2 in CTL-mediated tumor surveillance. Cancer Research 69:203-211

Stockinger, S., Kastner, R., Kernbauer, E., Pilz, A., Westermayer, S., Reutterer, B., Soulat, D., Stengl, G., Vogl, C., Frenz, T., Waibler, Z., Taniguchi, T., Rulicke, T., Kalinke, U., Müller, M. and Decker, T. (2009).
Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog 5, e1000355.

Stockinger, S., and Decker, T. (2009).
STATs and Infection. In JAK-STAT Pathway in Disease, A. Stephanou, ed. (Austin Texas USA: Landes Bioscience), pp. 43-57. URL: www.ncbi.nlm.nih.gov/books/NBK6266/ [book chapter]

van Zijl, F., Mair, M., Cziszar, A., Schneller, D., Zulehner, G., Huber, H., Eferl, R., Beug, H., Dolznig, H. and Mikulits, W. (2009).
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the invasive front. Oncogene 28(45):4022-33

van Zijl, F., Zulehner, G., Petz, M., Schneller, D., Kornauth, C., Hau, M., Machat, G., Grubinger, M., Huber, H. and Mikulits, W. (2009).
Epithelial to mesenchymal transition in hepatocellular carcinoma. Fut Oncol, 5(8):1169-79 (review).




Costantino G, Egerbacher M, Kolbe T, Karaghiosoff M, Strobl B, Vogl C, Helmreich M, Müller M. (2008)
Tyk2 and Signal Transducer and Activator of Transcription 1 Contribute to Intestinal I/R Injury. Shock 29, 238-244.

Gal A, Sjöblom T, Beug H, Moustakas A (2008)
Sustained TGFbeta signalling in NMuMG mammary epithelial cells abolishes proliferation arrest and favours epithelial plasticity and local invasion. Oncogene 27, 1218-1230.

Eferl, R., Hasselblatt, P., Rath, M., Popper, H., Zenz, R., Komnenovic, V., Idarraga, M.H., Kenner, L., and Wagner, E.F. (2008).
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci USA 105, 10525-10530.

Gratz N, Siller M, Schaljo B, Pirzada ZA, Gattermeier I, Vojtek I, Kirschning CJ, Wagner H, Akira S, Charpentier E, Kovarik P. (2008).
Group A Streptococcus activates type I interferon production and MYD88-dependent signalling without involvement of TLR2, TLR4 and TLR9. J. Biol. Chem., 283(29):19879-19887.

Grebien F, Kerenyi MA, Kovacic B, Kolbe T, Becker V, Dolznig H, Pfeffer K, Klingmuller U, Muller M, Beug H, Mullner EW*, Moriggl R.* (2008).
Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111, 4511-4522. *equal contribution

Grech G, Blazquez-Domingo M, Kolbus A, Bakker WJ, Müllner EW, Beug H, von Lindern M. (2008).
Igbp1 is part of a positive feed-back loop in SCF-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. Blood 112(7): 2750-2760.

Grunert T, Marchetti M, Miller I, Müller M, Allmaier G. (2008)
Comparing the applicability of CGE-on-the-chip and SDS-PAGE for fast pre-screening of, ouse serum samples prior to proteomics analysis. Electrophoresis 29 (21): 4332-4340.

Harir N, Boudot C, Friedbichler K, Sonneck K, Kondo R, Martin-Lannerée S, Kenner L, Kerenyi MA, Yahiaoui S, Gouilleux-Gruart V, Gondry J, Bénit L, Dusanter-Fourt I, Lassoued K, Valent P, Moriggl R, Gouilleux F. (2008).
Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI 3-kinase signaling cascade. BLOOD 112(6):2463-73

Harir N, Boudot C, Friedbichler K, Sonneck K, Kondo R, Kenner L, Kerenyi M, Gouilleux-Gruart V, Gondry J, Lassoued K, Valent P, Gouilleux F, Moriggl R. (2008).
Oncogenic Kit controls neoplastic mast cell development through a Stat5/PI 3-kinase signaling cascade. * equal contribution and correspondence. Blood, 111: 4511-4522.

Huber M, Steinwald V, Guralnik A, Brustle A, Kleemann P, Rosenplanter C, Decker T, Lohoff M (2008).
IL-27 inhibits the development of regulatory T cells via STAT3. Int. Immunol. 20, 223-234.

Kornfeld J, Grebien F, Kerenyi M, Friedbichler K, Kovacic B, Zankl B, Hoelbl A, Nivarti H, Beug H, Sexl V, Müller M, Mullner E, Kenner L, Gouilleux F, Moriggl R. (2008)
The Different Functions of Stat5 and Chromatin Alteration through Stat5 Proteins. Front. Biosci. 13, 6237-6254.

Kerenyi M, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Müllner E. (2008)
Stat5 regulates cellular iron uptake in erythroid cells via IRP-2 and TfR-1. Blood, 112: 2463-2473. (This paper received the ”Doc-Award” 2009 from the University of Vienna, sponsored by the City of Vienna, the "Promotion Award of the City of Vienna 2009"  (Förderungspreis der Stadt Wien) and was featured by the Austrian daily newspaper "Die Presse")

Mayerhofer M, Gleixner K, Hoelbl A, Florian S, Hoermann G, Aichberger K, Bilban M, Esterbauer H, Krauth M, Sperr W, Longley J, Kralovics R, Moriggl R, Zappulla J, Liblau R, Schwarzinger I, Sexl V, Sillaber C, Valent P. (2008)
Unique effects of kit D816V in Ba/F3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens. Journal of Immunology 80 (8), 5466-5476.

Mayerhofer M, Gleixner KV, Mayerhofer J, Hoermann G, Jaeger E, Aichberger KJ, Ott RG, Greish K, Nakamura H, Derdak S, Samorapoompichit P, Pickl WF, Sexl V, Esterbauer H, Schwarzinger I, Sillaber C, Maeda H, Valent  P. (2008).
Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood. 111(4):2200-2210.

Radwan M, Miller I, Grunert T, Vogl C, O'Donoghue N, Dunn M, Kolbe T, Marchetti M, Allmair G, Gemeiner M, Müller M, Strobl, B. (2008).
The impact of Tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS). Proteomics 8, 3469-3485. 

Reutterer B, Stockinger S, Pilz A, Soulat D, Kastner R, Westermayer S, Rulicke T, Müller M, Decker T. (2008).
Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence. Cell Microbiol. 10, 1116-1129.

Sadzak I, Schiff M, Gattermeier I, Glinitzer R, Sauer I, Saalmüller A, Yang E, Schaljo B, Kovarik P. (2008).
Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc. Natl. Acad. Sci .U.S.A. 105, 8944-8949.

Schneider A, Reichart U, Gerner W, Kolbe T, Saalmüller A, Müller M. (2008)
Selective contribution of Tyk2 to cell activation by lipopolysaccharide.
FEBS Lett. 582 (25-26): 3681-6.

Schuster C, Müller M, Freissmuth M,  Sexl V, Stoiber, D. (2008)
‘‘Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells’’ Biochem. Biophys. Res.Commun. 366, 869-870.

Soulat D, Burckstummer T, Westermayer S, Goncalves A, Bauch A, Stefanovic A, Hantschel O, Bennett KL, Decker T, Superti-Furga G. (2008).
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J. 27(15):2135-46.

Stockinger S, Decker T. (2008)
Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes. Immunobiology 213(9-10):889-897.

Tsyrulnyk A, and Moriggl R. (2008)
A Detailed Protocol for BAC Recombineering to Study Essential Genes in Stem Cells. Methods Mol Biol 430: 269-93 (review)

von Gabain A, Nagy E, Decker T. (2008).
Novel paradigms in vaccine development: from small pox eradication to therapeutic vaccines. Biol. Chem. 389, 455-456 (review)

Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier K, Kolbe T, Stulnig T, Hörl W, Hentstschläger M, Müller M, Säemann, M. (2008).
The TSC-m TOR Signaling Pathway Regulates the Innate Inflammatroy Response. Immunity, 29, 4, 565-577.

Zebedin, E., Simma, O., Schuster, C., Putz, E.M., Fajmann, S., Warsch, W., Eckelhart, E., Stoiber, D., Weisz, E., Schmid, J.A., Pickl, W.F., Baumgartner, C., Valent, P., Piekorz, R.P., Freissmuth, M., and Sexl, V. (2008).
Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance. Blood 112, 4655-4664.

Zenz R, Eferl R, Scheinecker C, Redlich K, Smolen, J, Schönthaler, HB, Kenner, L, Tschachler, E, Wagner, EF. (2008)
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Zwaferink H, Stockinger S,  Hazemi P, Lemmens-Gruber R, Decker T. (2008).
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Zwaferink H, Stockinger S, Reipert S, Decker T. (2008).
Stimulation of inducible nitric oxide synthase expression by interferon beta increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect. Immun. 76(4) 1649-1656




Aigner, K, Descovich, L, Mikula, M, Sultan, A, Dampier, B, Bonne, S, van Roy, F, Mikulits, W, Schreiber, M, Brabletz, T, Sommergruber, W, Schweifer, N, Wernitznig, A, Beug, H, Foisner, R, and Eger, A (2007)
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett 581, 1617-1624.

Aigner, K, Dampier, B, Descovich, L, Mikula, M, Sultan, A, Schreiber, M, Mikulits, W, Brabletz, T, Strand, D, Obrist, P, Sommergruber, W, Schweifer, N, Wernitznig, A, Beug, H, Foisner, R, and Eger, A (2007)
The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26, 3395-3405.

Bakiri L., Takada Y., Radolf M., Eferl R., Yaniv M., Wagner E. F. and Matsuo K. (2007)
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Blaas L, Musteanu M, Zenz R, Eferl R, Casanova E. (2007)
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del Prete M. J., Vernal R., Dolznig H., Mullner E. W. and Garcia-Sanz J. A. (2007)
Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments. Rna 13, 414-421.

Eferl, R., Zenz, R., Theussl, H. C., and Wagner, E. F. (2007)
Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis 45, 447-451.

Engblom, D., Kornfeld, J. W., Schwake, L., Tronche, F., Reimann, A., Beug, H., Hennighausen, L., Moriggl, R., and Schutz, G. (2007)
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21, 1157-1162

Fischer, AN, Fuchs, E, Mikula, M, Huber, H, Beug, H, and Mikulits, W (2007)
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26, 3395-3405

Gausterer, C., Müller, M., and Strobl, B. (2007)
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Harir N., Pecquet C., Kerenyi M., Sonneck K., Kovacic B., Nyga R., Brevet M., Dhennin I., Gouilleux-Gruart V., Beug H., Valent P., Lassoued K., Moriggl R. and Gouilleux F. (2007)
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Hui, L., Bakiri, L., Mairhorfer, A., Schweifer, N., Haslinger, C., Kenner, L., Komnenovic, V., Scheuch, H., Beug, H., and Wagner, E. F. (2007)
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Kovarik P, Sauer I, Schaljo B. (2007)
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Infante, A. A., Infante, D., Chan, M. C., How, P. C., Kutschera, W., Linhartova, I., Mullner, E. W., Wiche, G., and Propst, F. (2007)
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Li G, Wang Z, Zhang Y, Kang Z, Haviernikova E, Cui Y, Hennighausen L, Moriggl R, Wang D, Tse W, Bunting KD. (2007) 
STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.  Experimental Hematology, 35, 1684-1694

Mayerhofer, M., Gleixner, K.V., Mayerhofer, J., Hoermann, G., Jaeger, E. Aichberger, K.J., Ott, R.G., Greish, K., Nakamura, H.,  Derdak, S., Samorapoompichit, P., Pickl, W.F., Sexl, V., Esterbauer, H., Schwarzinger, I., Sillaber, C., Maeda, H., Valent, P. (2007)
Targeting of heat shock protein 32 (Hsp32) / heme oxygenase-1, (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib, Blood 111, 2200-2210.<s></s>

Mikula, M., Lahsnig, C., Fischer, A.N.M., Proell, V., Huber, H., Fuchs, E., Eger, A., Beug, H., and Mikulits, W. (2007)
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Ott, R. G., Simma, O., Kollmann, K., Weisz, E., Zebedin, E. M., Schorpp-Kistner, M., Heller, G., Zochbauer, S., Wagner, E. F., Freissmuth, M., and Sexl, V. (2007)
JunB is a gatekeeper for B-lymphoid leukemia. Oncogene 2007; 26, 4863-4871. 

Painz R., Walter I., Kolbe T., Riegler D., Vogl C., Steinborn R., Rülicke T., Helmreich M., Karaghiosoff M. and Müller M. (2007)
Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo. Immunobiology 212, 863-875.

Piskacek S, Gregor M, Nemethova M, Grabner M, Kovarik P, Piskacek M. (2007)
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Ramsauer K., Farlik M., Zupkovitz G., Seiser C., Kroger A., Hauser H. and Decker T. (2007)
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Staber, P.B., Vesely, P., Haq, N., Ott,  R.G., Funato, K., Bambach, I.,  Fuchs, C., Schauer, S., Linkesch, W.,  Hrzenjak, A.,  Dirks, W.G. Sexl,  V.,  Bergler, H., Kadin, M.E., Sternberg, D.W., Kenner, L. and Hoefler, G.  (2007)
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Tsareva S, Moriggl R, Corvinus F, Wiederanders B, Schütz A, Kovacic B, Friedrich K. (2007)
STAT3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia, 9, 279-291

Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B., Forster, I., Habenicht, A. J., Reichardt, H.M., Tronche, F., Schmid, W., and Schutz, G. (2007)
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Yao, Z, Kanno, Y, Kerenyi, M, Stephens, G, Durant, L, Watford, WT, Laurence, A, Robinson, GW, Shevach, EM, Moriggl, R, Hennighausen, L, Wu, C, and O'Shea, JJ (2007)
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Dolznig H., Grebien F., Deiner E. M., Stangl K., Kolbus A., Habermann B., Kerenyi M. A., Kieslinger M., Moriggl R., Beug H. and Mullner E. W. (2006)
Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR. Oncogene 25, 2890-2900.

Fischer A. N., Fuchs E., Mikula M., Huber H., Beug H. and Mikulits W. (2006) PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26, 3395-3405.

Hoelbl A., Kovacic B., Kerenyi M. A., Simma O., Warsch W., Cui Y., Beug H., Hennighausen L., Moriggl R. and Sexl V. (2006)
Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 107, 4898-906.

Jechlinger M., Sommer A., Moriggl R., Seither P., Kraut N., Capodiecci P., Donovan M., Cordon-Cardo C., Beug H. and Grunert S. (2006)
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Kovacic B., Stoiber D., Moriggl R., Weisz E., Ott R. G., Kreibich R., Levy D. E., Beug H., Freissmuth M. and Sexl V. (2006)
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Leitner N. R., Strobl B., Bokor M., Painz R., Kolbe T., Rulicke T., Muller M. and Karaghiosoff M. (2006)
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Mikhael M., Kim S. F., Schranzhofer M., Soe-Lin S., Sheftel A. D., Mullner E. W. and Ponka P. (2006)
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Mikula M., Proell V., Fischer A. N. and Mikulits W. (2006)
Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 209, 560-7.

Sauer I., Schaljo B., Vogl C., Gattermeier I., Kolbe T., Muller M., Blackshear P. J. and Kovarik P. (2006)
Interferons limit inflammatory responses by induction of tristetraprolin. Blood 107, 4790-4797.

Schranzhofer M., Schifrer M., Cabrera J. A., Kopp S., Chiba P., Beug H. and Mullner E. W. (2006)
Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis. Blood 107, 4159-4167.

Stepniak E., Ricci R., Eferl R., Sumara G., Sumara I., Rath M., Hui L. and Wagner E. F. (2006)
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 20, 2306-2314.

Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T., Schreiber M., Jechlinger M. and Beug H. (2006)
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell 10, 227-239.