- Jak-Stat Signalling
- Research Groups
- Group Eferl
Group Eferl
Stat3/Stat5 Functions in Inflammatory Liver Damage and Carcinogenesis
network contribution
Human hepatocellular carcinoma is frequently associated with inflammation and Hepatitis B virus infection. Reasonable animal models that express viral antigens in hepatocytes and develop inflammatorymediated human hepatocellular carcinomas have been established. Activation of the transcription factor Stat3 is frequently observed in hepatocellular carcinomas.
Key Hypothesis:
- Inflammation and liver cancer progression is molecularly linked via paracrine activation of Stat3 signalling in hepatocytes.
Contact
Ludwig Boltzmann Institute for Cancer Research (LBI-CR)
Währingerstr. 13A
A-1090 Vienna, Austria
phone: +43-1-4277-64111
fax: +43-1-4277-9641