Logo fwf - Der Wissenschaftsfonds


1st AEGEAN International Conference on CYTOKINE SIGNALING IN CANCER held in Chania, Crete, Greece on May 24-29, 2015


Antwort auf/zuklappen AEGEAN CONFERENCE


EMBC DELEGATE AND SCIENTIFIC ADVISOR (MAY 2014)
VERONIKA SEXL NOMINATED BY THE AUSTRIAN GOVERNMENT


Antwort auf/zuklappen EUROPEAN MOLECULAR BIOLOGY CONFERENCE (EMBC)


HIGHLIGHT IN THE ICIS NEWSLETTER (APRIL 2014)
AUSTRIAN JAK/STAT COOPERATIVE


Antwort auf/zuklappen SIGNALS - THE INTERNATIONAL CYTOKINE & INTERFERON SOCIETY (ICIS) NEWSLETTER


PAPER RELEASE (APRIL 2014)
STAT1 ISOFORMS: BROTHERS IN ARMS


(Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, A1210 Vienna, Austria; University Center Biomodels Austria, University of Veterinary Medicine Vienna, A1210 Vienna, Austria; Department of Virology University of Freiburg, D79104 Freiburg, Germany; Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg; Institute of Biotechnology in Animal Production, Department IFA-Tulln, University of Natural Resources and Life Sciences, A3430 Tulln, Austria; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, A1210 Vienna, Austria; Max F. Perutz Laboratories, University of Vienna, A1030 Vienna, Austria) concerning our paper:

STAT1β is not dominant negative and is capable of contributing to IFNγ-dependent innate immunity

Christian Semper, Nicole R. Leitner, Caroline Lassnig, Matthias Parrini, Tanel Mahlakõiv, Michael Rammerstorfer, Karin Lorenz, Doris Rigler, Simone Müller, Thomas Kolbe, Claus Vogl,T homas Rülicke, Peter Staeheli, Thomas Decker, Mathias Müller, and Birgit Strobl is published online in Mol Cell Biol 2014 Apr 7. [Epub ahead of print] doi: 10.1128/MCB.00295-14

Antwort auf/zuklappen STAT1 ISOFORMS: BROTHERS IN ARMS


PAPER RELEASE (JANUARY 2014)
A HEALTHY BALANCE - A MODEL FOR STUDYING CANCER AND IMMUNE DISEASES


(Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria; University Center Biomodels Austria (BIAT), University of Veterinary Medicine Vienna, Austria; Clinical Institute of Pathology, Medical University of Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria; Department of Internal Medicine I, Institute for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Austria; Department IFA-Tulln, Biotechnology in Animal Production, University of Natural Resources and Applied Life Sciences, Tulln, Austria; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Vienna, Austria) concerning our paper:
Inducible, Dose-Adjustable and Time-Restricted Reconstitution of Stat1 Deficiency In Vivo
Nicole R. Leitner, Caroline Lassnig, Rita Rom, Susanne Heider, Zsuzsanna Bago-Horvath, Robert Eferl, Simone Müller, Thomas Kolbe, Lukas Kenner, Thomas Rülicke, Birgit Strobl, and Mathias Müller is published online in PLoS ONE (9(1): e86608. doi:10.1371/journal.pone.0086608)

Antwort auf/zuklappen A HEALTHY BALANCE - A MODEL FOR STUDYING CANCER AND IMMUNE DISEASES


paper release (november 2013)
A stop sign for cancer


(Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria; Genetics, Immunotherapy, Chemistry and Cancer (GICC) CNRS, Université François Rabelais, Tours, France; Department of Laboratory Medicine, Medical University of Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna, Austria) concerning our paper:
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis
Angelika Berger, Andrea Hoelbl-Kovacic, Jérôme Bourgeais, Lukas Hoefling, Wolfgang Warsch, Eva Grundschober, Iris Z. Uras, Ingeborg Menzl, Eva Maria Putz, Gregor Hoermann, Christian Schuster, Sabine Fajmann, Ernestine Leitner, Stefan Kubicek, Richard Morigglf Fabrice Gouilleu and Veronika Sexl is published online in Leukemia (2013 Nov 22. doi: 10.1038/leu.2013.351).

Antwort auf/zuklappen A STOP SIGN FOR CANCER


paper release (august 2013)
STATic KILLERS?


(Institute of Pharmacology and Toxicology, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Austria; Research Institute of Molecular Pathology, Vienna, Austria; Institute of Animal Breeding and Genetics, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Austria; Max F. Perutz Laboratories, University of Vienna, Austria; Institute of Immunology, Medical University of Vienna, Austria; Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Austria) concerning our paper:
CDK8-Mediated STAT1-S727 Phosporylation Restrains NK Cell Cytotoxicity and Tumor Surveillance.
Eva Maria Putz, Dagmar Gotthart, Gregor Hoermann, Agnes Csiszar, Silvia Wirth, Angelika Berger, Elisabeth Straka, Doris Rigler, Barbara Wallner, Amanda M. Jamieson, Winfried F. Pickl, Eva Maria Zebedin-Brandl, Mathias Müller, Thomas Decker and Veronika Sexl is published in the current issue of Cell Reports (4, 437-444, August 15, 2013; http://dx.doi.org/10.1016/j.celrep.2013.07.012)

Antwort auf/zuklappen STATic KILLERS?


paper release (august 2013)
MORE THAN JUST A KINASE: CDK6 IN CANCER


(Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Austria; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria; Clinical Division of Oncology, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Austria; Institute of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Austria; Department of Clinical Pathology, Medical University of Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Austria; Department of Dermatology, Medical University of Vienna, Austria; Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria; Department of Pathology, Medical University of Graz, Austria; Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute and Department of Hematology, University of Cambridge, UK; Department of Hematology, Addenbrooke’s Hospital, Cambridge, UK; Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncolo´ gicas (CNIO), Madrid, Spain) concerning our paper:
A new kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.
Karoline Kollmann, Gerwin Heller*, Christine Schneckenleithner*, Wolfgang Warsch*, Ruth Scheicher, Rene G. Ott, Markus Schäfer, Sabine Fajmann, Michaela Schlederer, Ana-Iris Schiefer, Ursula Reichart, Matthias Mayerhofer, Christoph Hoeller, Sabine Zoechbauer-Mueller, Dontscho Kerjaschki, Christoph Bock, Lukas Kenner, Gerald Hoefler, Michael Freissmuth, Anthony R. Green, Richard Moriggl, Meinrad Busslinger, Marcos Malumbres and Veronika Sexl is published in the current issue of Cancer Cell (24, 167-181, August 12, 2013; http://dx.doi.org/10.1016/j.ccr.2013.07.012)
* equal contribution

Antwort auf/zuklappen MORE THAN JUST A KINASE: CDK6 IN CANCER


AWARDS TO YOUNG SCIENTISTS (MARCH 2013)


Antwort auf/zuklappen Three young investigators of the goup of Veronika were awarded the prizes ‘Funds of the City of Vienna for Innovative Interdisciplinary Cancer Research’ for their first authorship publications:


Now available: Registration for the 2nd FEBS Special Meeting on JAK-STAT Signalling: Model Organisms and Beyond, Nottingham, UK, 12-15 September 2013


Antwort auf/zuklappen http://nott.ac.uk/jakstat2013; Maureen Mee


FWF Board Decision (December 2012)


Antwort auf/zuklappen SFB F28 ,Jak-Stat Signalling: From Basics to Disease’ Funded until 2016


paper release (october 2012)
OF MICE AND MAN


(Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria; Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria; Institute of Pharmacology and Toxicology, Veterinary University Vienna, Vienna, Austria; Institute of Pathology, Medical University of Graz, Graz, Austria; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria; Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department of the Paracelsus Medical University, Salzburg, Austria; Department of Internal Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria; Division of Hematology, Medical University of Graz, Graz, Austria; Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, USA; Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Pathology and Hematopathology Unit, Department of Hematology and Oncology 'L. and A. Seràgnoli,' S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Comprehensive Cancer Center Drug & Target Screening Unit, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster Oncology, Vienna, Austria; Department of Molecular Biotechnology and Health Science, Center for Experimental Research and Medical Studies, University of Turin, Turin, Italy; Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, New York, USA; Department of Oncological Sciences, University of Turin, Turin, Italy; Laboratory of Oncogenomics, Institute for Cancer Research and Treatment, Candiolo, Italy; Worldwide Discovery Research, Cephalon, Inc., West Chester, Pennsylvania, USA; Department of Internal Medicine I, Institute for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna, Austria) concerning our paper:
PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas. Daniela Laimer*, Helmut Dolznig*, Karoline Kollmann*, Paul W Vesely*, Michaela Schlederer, Olaf Merkel, Ana-Iris Schiefer, Melanie R Hassler, Susi Heider, Lena Amenitsch, Christiane Thallinger, Philipp B Staber, Ingrid Simonitsch-Klupp, Matthias Artaker, Sabine Lagger, Suzanne D Turner, Stefano Pileri, Pier Paolo Piccaluga, Peter Valent, Katia Messana, Indira Landra, Thomas Weichhart, Sylvia Knapp, Medhat Shehata, Maria Todaro, Veronika Sexl, Gerald Höfler, Roberto Piva, Enzo Medico, Bruce A Ruggeri, Mangeng Cheng, Robert Eferl, Gerda Egger, Josef M Penninger, Ulrich Jaeger, Richard Moriggl, Giorgio Inghirami & Lukas Kenner is published online in the journal Nature Medicine 2012. doi: 10.1038/nm.2966.
* equal contribution

Antwort auf/zuklappen Of mice and men


paper release (july 2012)
TAKING A HIT OR TWO


(Ludwig Boltzmann Institute for Cancer Research, Vienna Austria; Spanish National Cancer Research Centre (CNIO), Madrid Spain; Institute of Molecular Biotechnology (IMBA), Vienna Austria; Institute of Animal Breeding and Genetics, Vetmeduni Vienna Austria; Institute of Laboratory Animal Science and Biomodels Austria, Vetmeduni Vienna Austria; Department Agrobiotechnology, Institute of Biotechnology in Animal Production, University of Natural Resources and Applied Life Sciences, Tulln Austria; Clinical Institute of Pathology, Medical University of Vienna (MUW) Austria; Institute of Pharmacology, MUW Vienna Austria; Institute of Pathology, Medical University of Graz, Austria; Institute of Cancer Research, MUW Vienna Austria) concerning our paper:
A mouse model to identify cooperating signaling pathways in cancer Monica Musteanu*, Leander Blaas*, Rainer Zenz, Jasim Svinka, Thomas Hoffmann, Beatrice Grabner, Daniel Schramek, Hans-Peter Kantner, Mathias Müller, Thomas Kolbe, Thomas Rülicke, Richard Moriggl, Lukas Kenner, Dagmar Stoiber, Josef Penninger, Helmut Popper, Emilio Casanova and Robert Eferl is published online in the journal Nature Methods 2012, DOI: 10.1038/nmeth.2130
* equal contribution

Antwort auf/zuklappen TAKING A HIT OR TWO


paper release (june 2012)
A MOUSE MODEL TO DISSECT TYK2 KINASE-DEPENDENT AND –INDEPENDENT FUNCTIONS


(Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Austria; Biomodels Austria, University of Veterinary Medicine Vienna; Genetic Reprogramming Group Agricultural Biotechnology Center, Gödöllö Hungary; Department for Agrobiotechnology IFA Tulln, University of Natural Resources and Life Sciences Vienna; Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, Austria; Molecular Animal Biotechnology Laboratory Szent Istvan University and BioTalentum Ltd., Gödöllö Hungary) concerning our paper:
TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo Michaela Prchal-Murphy, Christian Semper, Caroline Lassnig, Barbara Wallner, Christian Gausterer, Ingeborg Teppner-Klymiuk, Julianna Kobolak, Simone Müller, Thomas Kolbe, Marina Karaghiosoff, Andras Dinnyés, Thomas Rülicke, Nicole R. Leitner, Birgit Strobl and Mathias Müller is published online in the journal PLoS ONE (7(6): e39141. doi:10.1371/journal.pone.0039141)

Antwort auf/zuklappen A MOUSE MODEL TO DISSECT TYK2 KINASE-DEPENDENT AND –INDEPENDENT FUNCTIONS


paper release (june 2012)
CELL TYPE SPECIFIC REQUIREMENTS OF STAT1 FOR THE DEFENCE AGAINST LISTERIA MONOCYTOGENES


(Max F. Perutz Laboratories, University of Vienna; Ludwig Boltzmann Institute for Cancer Research, Vienna; Institute of Pharmacology, Centre for Physiology and Pharmacology, Medical University of Vienna; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna; Biomodels Austria, University of Veterinary Medicine Vienna; Department of Microbiology and Immunology, Columbia University Medical Center, New York, United States of America; Twincore, Center for Experimental and Clinical Infection Research, Hannover, Germany) concerning our paper:
Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection. Kernbauer, Verena Maier, Dagmar Stoiber, Birgit Strobl, Christine Schneckenleithner, Veronika Sexl, Ursula Reichart, Boris Reizis, Ulrich Kalinke, Amanda Jamieson, Mathias Müller and Thomas Decker is published online in the journal PLoS Pathogens (8(6): e1002763. doi:10.1371/journal.ppat.1002763)

Antwort auf/zuklappen CELL TYPE SPECIFIC REQUIREMENTS OF STAT1 FOR THE DEFENCE AGAINST LISTERIA MONOCYTOGENES


EUROPEAN HEMATOLOGY ASSOCIATION FELLOWSHIPS & GRANTS COMMITTEE MEMBERSHIP (JUNE 2012)


Antwort auf/zuklappen Veronika Sexl has accepted the honourable invitation to join the Fellowships and Grants Committee of the European Hematology Association (EHA)


Online Available: ‘Jak-Stat Signaling: From Basics to Disease’, Thomas Decker & Mathias Müller (Eds.)


Antwort auf/zuklappen ‘Jak-Stat Signaling: From Basics to Disease’ - A comprehensive book about Jaks, Stats and signal transduction


Award to young scientist (march 2012)


Antwort auf/zuklappen A young investigator of the group of Veronika Sexl was recently awarded the following prize:


paper release (january 2012)
JAK OF ALL TRADES? NOT OF LEUKAEMIA THERAPY!


(University of Veterinary Medicine Vienna; CeMM Research Center Austrian Academy of Sciences, Vienna; Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland; Medical University of Vienna; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA) concerning our paper:
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Oliver Hantschel*, Wolfgang Warsch*, Eva Eckelhart*, Ines Kaupe, Florian Grebien, Kay-Uwe Wagner, Giulio Superti-Furga° and Veronika Sexl° is published online in the journal Nature Chemical Biology (2012, Vol. 8; doi: 10.1038/nchembio.775.).
* equal contribution
° corresponding authors

Antwort auf/zuklappen JAK OF ALL TRADES? NOT OF LEUKAEMIA THERAPY!


AWARDS TO YOUNG SCIENTISTS (OCTOBER 2011)



Antwort auf/zuklappen Young investigators of the groups of Veronika Sexl and Thomas Decker were recently awarded for their scientific work the following prizes:


Hartmut Beug 1945-2011


We sadly announce that Hartmut Beug passed away on 3 July 2011
In memoriam


paper release (june 2011)
REVIEWING THE FUNCTIONS OF TYK2, STAT3 And STAT5 IN HOST IMMUNITY AND CARCINOGENESIS


(Vetmeduni Vienna, Ludwig Boltzmann Institute for Cancer Research, Medical University of Vienna)
The June issue of the Landmark Edition of Frontiers in Biocience (http://www.bioscience.org/current/currissu.htm) publishes three reviews on Jak-Stat functions in disease of members of the Vienna Jak-Stat consortium.

Antwort auf/zuklappen Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation

Antwort auf/zuklappen JAK-STAT signaling in hepatic fibrosis

Antwort auf/zuklappen Tyrosine kinase 2 (Tyk2) in cytokine signalling and host immunity


paper release (february 2011)
Natural (born) killers: what do they really do?


(Vetmeduni Vienna, Medical University of Vienna, Ludwig Boltzmann Institute for Cancer Research) concerning our paper:
A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK cell survival and development. Eva Eckelhart, Wolfgang Warsch, Eva-Maria Zebedin, Olivia Simma, Dagmar Stoiber, Thomas Kolbe, Thomas Rülicke, Mathias Mueller, Emilio Casanova and Veronika Sexl. Blood, Vol.117, Issue 5, Feb. 2011

Antwort auf/zuklappen Natural (born) killers: what do they really do?


press report (july 2010)
Quis custodiet ipsos custodies? How cells keep their guards in check


(University Vienna, Vetmeduni Vienna) concerning our paper:
Nonconventional Initiation Complex Assembly by STAT and NF-kB Transcription Factors Regulates Nitric Oxide Synthase Expression. Matthias Farlik, Benjamin Reutterer, Christian Schindler, Florian Greten, Claus Vogl, Mathias Müller, Thomas Decker. Immunity, Vol.32, issue 7, July 2010.

Antwort auf/zuklappen Quis custodiet ipsos custodies? How cells keep their guards in check