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•   Jak-Stat Signalling
•   Meeting 2010

General Information

Important Dates and Deadlines

• August 18, 2009            Start of online registration
• December 15, 2009       Deadline for online registration and abstract submission
• December 20, 2009   Letters of acceptance and detailed course information will be e-mailed to all participants

Fees

Early registration fee is € 170,- for payments until December 31^th, 2009, for all participants. After this date the regular registration fee is € 220,-.

The registration fee includes meals during the lectures.

No payments may be made before notification of acceptance has been received from the organisers on 20^th December 2009.

Poster Dimension

Maximum allowed size for a poster is 150cm height by 120cm width (=59" h x 47" w [inches]). The posters will by attached to the boards with pins supplied by the organiser.

Network

Free wireless network will be available at the conference site

Registration and Abstract Submission

Online Registration under the following link:
http://www.jak-stat.at/reg/index.php

Deadline: 15^th December 2009

E-mail: jakstat@punkt-international.eu

Fellowships:
Fellowships & Grants

Preliminary Scientific Programme

Jak-Stat Signalling: From Basics to Disease
February 10^th, 2010 - February 13th, 2010

MEETING PROGRAM

Wednesday (Feb 10^th):

17:00 - 18:00       Registration/Beverages

18:00 - 18:45       Keynote I: Jim Darnell (New York/USA): Looking back in order
                             to look forward

18:45 – 19:45      Get together

Thursday (Feb 11th):

Session I             Jak/Stat Structure and Regulation:

9:00- 9:25            Uwe Vinkemeier (Nottingham/UK): Cytokine-Induced
                             Paracrystals of Activated STATs Facilitate the Cross-Regulation
                             of Signaling Pathways by Interferon-gamma

9:25 -9:50            Fred Schaper (Aachen/GER): More than JAKs and STATs:
                             New insights into the regulation of Interleukin-6 signal
                             transduction

20 min                  Coffee-break

10:10-10:35         Sandra Pellegrini (Paris/Fr): Parameters Governing Interferon
                             Alpha2/Beta Differential Activities

10:35-10:50         Serge Haan: (Luxembourg/Lux): Regulation of Jak activity-
                             structural and functional considerations

10:50-11:05         Gerhard Müller-Newen (Aachen/Ger): The role of N-terminal
                             domain in dimerization and nucleocytoplasmic shuttling of
                             latent Stat3

11:05-11:15         Gerardo Ferbeyre (Montreal/Can): Regulation of the p53
                             pathway by the suppressor of cytokine signaling-1

15 min                  Coffee-break

Session II            Negative regulation:

11:35-12:00         Doug Hilton (Melbourne/Aus): Genetic dissection of signalling
                             pathways

12:00-12:25         Jim Johnston (Belfast/UK): SOCS2 deficiency results in an
                             enhanced TH2 differentiation and allergic responses

12:25-14:00 Lunch break and 1^st poster session

14:00- 14:25        Thorsten Heinzel (Jena/Ger):

14:25- 14:40        Vijay Shanker (Basel/Ch): Protein Phosphatase 2° is a
                             negative regulator of inbterfeon signaling through the Jak-Stat 
                             pathway

Session III           Transcriptional Regulation and Epigenetics:

14:40-15:05         Rod Bremner (Toronto/Can): New epigenetic components in
                             the Interferon signaling network

15:05- 15.25        Olli Silvennoinen (Tampere/Fin): Insights into the functional
                             domains of JAK2

15:25- 15:40        Shreevrat Goenka (Indianapolis/USA): PARP-14 functions as
                             a  transcriptional swirtch for Stat6 dependent transcription

20 min                  Coffee-break

16:00-16:25         Ana Costa-Pereira (London/UK): Novel components of
                             JAK/STAT signalling pathways identified using FACS-based 
                             siRNA screens

16:25-16:50         Willis Li (Rochester/USA): Non-canonical JAK/STAT Signaling:
                             A Role in Heterochromatin Stability

16:50-17:05         Mario Köster (Braunschweig/Ger): Temporal and spatial
                             resolution of type I and type III IFN responses in vivo

Friday (Feb 12^th):

Session IV          Jaks, Stats and Cancer:

9:00-9:45             Keynote II: George Stark (Cleveland/USA): Novel
                             posttranslational modifications of STAT1 and STAT3

9.45-10:10           David Levy (New York/USA): Non-canonical functions of STAT3
                             in growth and tumorigenesis

10:10-10:35         Valeria Poli (Torino/It): Oncogenic activities of constitutively
                             active STAT3

20 min                  Coffee-break

10:55-11:20         Mark Dawson (Cambridge/UK): Chromatin Modification – a
                             Nuclear Role for Jak2

11:35-12:00         Friedemann Horn (Leipzig/Ger):

12.00-12:15         Antonis Koromilas (Montreal/Can): ErbB2 signals to Stat1
                             with significant implications in transformation and mammary 
                             gland tumourigenesis

12:15-14:00        Lunch break and 2^nd poster session

Session V:         Jaks and Stats in Immune Responses to Tumors:

14:00-14:25         Ruby Chan (St. Louis/USA):

14:25-14.50         Giorgio Inghirami (Torino/It):

14:50-15:15         Shai Izraeli (Tel Aviv/Isr): The CRLF2-JAK-STAT pathway in
                             acute lymphoblastic leukemias

15:15-15:30         Anthony Green (Cambridge/UK): Molecular pathogenesis of
                             the myeloproliferative disorders

20 min                  Coffee-break and poster viewing

Session VI          Jaks and Stats in Infection, Inflammation and Autoimmunity:

15:50-16:15         Chris Schindler (New York/USA): Interferons direct an
                             effective innate response to Legionella pneumophila infection

16:15-16:40         Curt Horvath (Chicago/USA): Activation and Inhibition of
                             Interferon Signaling and Antiviral Responses

16:55-17:20         Ulrich Kalinke (Hannover/Ger): Local type I IFN receptor
                             signaling protects against virus spread within the central
                             nervous system

17:20-17:35         Iain L. Campbell (Sydney/Aus): Interferon (IFN)-alpha
                             mediates lethal inflammatory disease in the brain in the
                             absence of interferon regulatory factor (IRF) 9

Saturday (Feb 13^th):

Session VII         Development and Cell Differentiation:

9:00-9:25             Kay-Uwe Wagner (Lincoln/USA): The significance of
                             Jak2/Stat5 signaling for mammary development and
                             tumorigenesis

9.25-9:50             Lothar Hennighausen (Bethesda/USA): Cytokine-STAT5
                             signaling in mammary stem and progenitor cells

9:50-10:15           Isabelle Dusanter-Fourt (Paris/Fr): Stat5a and Stat5b : two
                             false-twins regulating hematopoiesis and carcinogenesis

10:15-10:30         Christine Watson (Cambridge/UK): Stat3 regulates cell
                             death by modulating PI3K signalling and cathepsin activity in
                             involuting mammary gland

20 min                  Coffee-break and poster viewing

Session VIII:      Jaks and Stats in the regulation of Immunity and Immunopathology:

10:50-11:15         John O’Shea (Bethesda/USA):

11:15-11:40         Mark Kaplan (Indianapolis/USA): Programming of T helper
                             cells by STAT proteins

11:40-12:05         Christine Biron (Providence/USA): Type 1 IFN Effects: Stat4-
                             and Stat1-Dependent Mechanisms for Regulating NK and CD8 T
                             Cell Responses during Viral Infections

12.05-12:20         Stephanie S. Watowich (Houston/USA): Regulation of
                            plasmacytoid dendritic cell development by STATs

12:20 - 12:35       Katherine J. Seidl (Cambridge/USA): Selective functional
                             inhibition of Jak3 kinase is sufficient for efficacy in collagen-
                             induced arthritis in mice

12:35 - 13:00       Poster-Award

13:00 - 13:30       Conclusive Remarks of Organisers / Beverages / End
                             of Meeting

Social Programme

Under Progress.

Speakers List

Christine A. Biron:  Brown University (Providence - USA)
Rod Bremner:  Toronto Western Hospital (Toronto - Canada)
S. Ruby Chan:  Washington University School of Medicine (St. Louis, USA)
Ana Costa-Pereira:  Imperial College London (London - UK)
James E. Darnell:  The Rockefeller University (New York - USA)
Mark Dawson: University of Cambridge (Cambridge - UK).
Isabelle Dusanter-Fourt:  Institut Cochin (Paris - France)
Thorsten Heinzel: Friedrich-Schiller-University Jena (Jena – Germany)
Lothar Hennighausen:  NIDDK, National Institutes of Health (Bethesda -USA)
Doug Hilton:  The Walter And Eliza Hall Institute of Medical Research (Victoria - Australia)
Friedemann Horn:  University Hospital Leipzig (Leipzig, Germany)
Curt M. Horvath:  Northwestern University (Evanston - USA)
Giorgio Inghirami: NYU Medical Center (New York - USA)
Jim Johnston:  Queen's University Belfast (Belfast - UK)
Ulrich Kalinke:  Twincore-Centre for Experimental and Clinical Infection Research (Hannover, Germany)
Mark H. Kaplan:  Indiana University School of Medicine (Indianapolis - USA)
David E. Levy:  NYU Medical Center (New York - USA)
Willis Li: University of Rochester Medical Center (New York – USA)
John J. O'Shea:  University of Cincinnati (Bethesda - USA)
Sandra Pellegrini:  Institut Pasteur (Paris - France)
Valeria Poli:  University of Turin (Turin - Italy)
Fred Schaper:  University Hospital Aachen, AÖR (Aachen - Germany)
Christian W. Schindler:  Columbia University (New York - USA)
Olli Silvennoinen: University of Tampere (Tampere - Finland)
George R. Stark:  Lerner Research Institute (Cleveland - USA)
Uwe Vinkemeier:  Nottingham University Medical School (Nottingham - UK)
Kay-Uwe Wagner: University of Nebraska Medical Center (Omaha - USA)

Organisers

Scientific Organiser:

Mathias Müller
University of Veterinary Medicine Vienna, Vienna, Austria

Thomas Decker
University of Vienna, Vienna, Austria

Administrative Organiser:

punkt international GmbH
Vienna, Austria

Venue / Hotel & Travel

The meeting will be located in the festival room of the University of Veterinary Medicine Vienna. The festival room provides seating for around 280 people and an adjoining hall for the poster presentations.

The University of Veterinary Medicine is the only academic veterinary institution in Austria and the oldest in the German speaking countries (founded in 1765).
Since 1996 the university campus is located in the 21st district of Vienna. About 1000 employees and 2300 students are working on this campus that also includes the university's animal hospital, spin-off-enterprises and branches of business partners.

As the University of Veterinary Medicine does not offer housing facilities, accommodation has to be organised individually.
You may contact one of the following hotels close to the University or the city center:

Reservation Keyword: “Jak-Stat”
Please note that the below-stated prices of our contingents are only valid until 15^th December 2009.

From Westbahnhof:

• Undergroundstation U6 (direction: Floridsdorf) -> Floridsdorf
• Tram no. 26 (direction Oberdorfstraße) ->Josef Baumanngasse/University of Veterinary Medicine

From South:

• U1 (direction: Leopoldau) -> to Kagraner Platz
• Tram no. 26 (direction: Strebersdorf) -> Josef Baumanngasse/University of Veterinary Medicine

or

• U1 (direction: Leopoldau) -> Kagran
• Bus no. 27A -> University of Veterinary Medicine

With high-speed railway:

• High-speed railway no. S1 (direction Gänserndorf) or S2 (direction Mistelbach) or S3 (direction Hollabrunn) or S15 (direction Floridsdorf) -> Floridsdorf
• Tram 26 (direction Oberdorfstraße) -> Josef Baumanngasse/University of Veterinary Medicine.

Travel from Airport Schwechat

• Bus from the airport directly to U1-Station Vienna International Center/UNO-City
• U1 (direction Leopoldau) to Kagraner Platz
• Tram no. 26 (direction of Edmund Hawranek-Platz -> Josef Baumann Gasse/Veterinary Medicine University.